15 KB445 KB14 KB199220252003Adamicová, KatarínaChríbiková, IvetaJautová, JagienkaPéč, JurajPéč, Martinletnik:12številka:3str. 89-93ISSN:1318-4458COBISSID:17000921URN:URN:NBN:SI:doc-8X3QSKT8enSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaBiopsijaBiopsyChilddermatologijaDrug Therapykožne bolezniMast CellsOtrokPathologyTkivni bazofilciUrticaria PigmentosaUrtikarija pigmentnaRegression of dermal mast cell infiltrates in patients with cutaneous mastocytosis|Background. Fourteen children with urticaria pigmentosa (UP) and two with disseminated cutaneous mastocytosis (DCM) were followed. Methods. Three skin biopsies were performed: the first one before the age of 2 years, the second one after 1-year treatment and the third 6 years after the second. Results. The repeated biopsy after the 1-year treatment resulted in a 20-60% regressionof the mast cell infiltrates, while the third one disclosed a 70-90%reduction of these infiltrates. In UP patients the mast cell infiltrate changed from vessel unit type >55 micro m to <55 micro m. In both the DCM patients the mast cell infiltrate changed into the type >55 micro m. In the two nontreated UP patients the mast cell infiltrate type remained <55 micro m.Conclusion: The authors observed a spontaneous regression of the mast cell infiltrates in mastocytosis patients during adolescence; the treatment can however essentially influence their reductionTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov