{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-892WX20E/182ff3b8-8414-4fee-9628-f7c21f3663ce/PDF","dcterms:extent":"288 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-892WX20E/38f8374e-cfc8-4eb2-850b-b1ba5af3ed69/TEXT","dcterms:extent":"28 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-892WX20E","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2016","dc:creator":["Draksler, Petra","Janković, Biljana","Lamešić, Dejan"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:67"},{"@xml:lang":"sl","#text":"str. 265-272"}],"dc:identifier":["ISSN:0014-8229","COBISSID:4102001","URN:URN:NBN:SI:doc-892WX20E"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"farmacevtski pripravki"},{"@xml:lang":"sl","#text":"fizikalno kemijske lastnosti"},{"@xml:lang":"sl","#text":"HPMC"},{"@xml:lang":"sl","#text":"ksantan"},{"@xml:lang":"sl","#text":"naravni polimeri"},{"@xml:lang":"sl","#text":"ogrodne tablete"},{"@xml:lang":"sl","#text":"tablete"},{"@rdf:resource":"http://www.wikidata.org/entity/Q423846"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Fizikalne lastnosti polimerov v farmaciji - ali jih poznamo?| Physical properties of polymers used in pharmacy - do we really know them?|"},"dc:description":[{"@xml:lang":"sl","#text":"The main components of matrix tablets are hy- drophilic polymers, which swell and form gels in contact with water and therefore control drug re- lease. Generally utilized polymers for this purpose are categorized as natural (xanthan), synthetic (poly- ethylene oxide) and semi-synthetic (hydroxypropyl- methylcellulose). Understanding of their physico- chemical characteristics and variability such as molecular weight, viscosity, type of substitute and degree of substitution, critical polymer concentration as well as size and shape of polymer chain are es- sential for formulation of robust tablets with desired release kinetics. In this review, the most important physico-chemical properties for formulation of ma- trix tablets are elaborated at examples of hydrox- ypropylmethylcellulose, polyethylene oxide and xan- than"},{"@xml:lang":"sl","#text":"Osnovni gradniki hidrofilnih ogrodnih tablet so poli- meri, ki ob stiku z vodo (medijem) nabrekajo in tvorijo gel ter s tem nadzirajo sproščanje zdravilne učinkovine oziroma njeno biološko uporabnost. V ta namen v večini primerov uporabljamo naravne (ksantan), sintezne (polietilenoksid) in polsintezne polimere (hidroksipropilmetilcelulozo). Poznavanje fizikalno-kemijskih lastnosti polimerov in njihove va- riabilnosti, kot so porazdelitev molske mase (stopnja polimerizacije), viskoznost, vrsta substituenta in stopnja substitucije, kritična koncentracija polimera ter oblika in velikost polimerne verige, so ključni za načrtovanje robustnih sistemov z želeno kinetiko sproščanja. Na primerih hidroksipropilmetilceluloze, polietilenoksida in ksantana v članku predstavljamo najpomembnejše fizikalno-kemijske lastnosti poli- merov za tvorbo ogrodnih tablet"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-892WX20E","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-892WX20E"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-892WX20E/182ff3b8-8414-4fee-9628-f7c21f3663ce/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-892WX20E/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-892WX20E"}}}}