{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-7UVU3XBH/6cf93b5f-b0ce-48cd-8343-757648a8bd33/PDF","dcterms:extent":"282 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-7UVU3XBH/e25f1389-8fd8-4ea9-8f2f-86f461e75e3d/TEXT","dcterms:extent":"25 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-7UVU3XBH","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2016","dc:creator":["Kocbek, Petra","Kristl, Julijana","Petelin, Milan","Zupančič, Špela"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:67"},{"@xml:lang":"sl","#text":"str. 303-309"}],"dc:identifier":["ISSN:0014-8229","COBISSID:4103025","URN:URN:NBN:SI:doc-7UVU3XBH"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"en","#text":"antibiotic"},{"@xml:lang":"sl","#text":"antibiotiki"},{"@xml:lang":"sl","#text":"nanodelci"},{"@xml:lang":"sl","#text":"nanodostavni sistemi"},{"@xml:lang":"sl","#text":"nanovlakna"},{"@xml:lang":"sl","#text":"parodontalna bolezen"},{"@xml:lang":"sl","#text":"Parodontalne bolezni"},{"@rdf:resource":"http://www.wikidata.org/entity/Q12187"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Nanozdravila za lokalno zdravljenje parodontalne bolezni| Nanomedicines for the local treatment of periodontal disease|"},"dc:description":[{"@xml:lang":"sl","#text":"Periodontal disease is a chronic inflammation of periodontal tissues resulting in destruction of the periodontal ligament, root cementum, and alveolar bone, formation of periodontal pockets and teeth loss. In numerous cases, the treatment according to the current guidelines does not lead to the desired outcome, and consequently, new approaches and medicines are under development. In this review article, different possible approaches are presented, which are (I) reduction of pathogen bacteria and establishment of a nor- mal oral flora, (II) host modulation therapy, and (III) improvement of tissue regeneration mostly with nanomedicines, such as liposomes, nanopar ticles, and nanofibers loaded with a drug. Nanomedicines can enable prolonged retention and controlled drug release at the targeted site; moreover, nanofibers can also increase periodontal disease regeneration"},{"@xml:lang":"sl","#text":"Parodontalna bolezen je kronično vnetje obzobnih tkiv, ki vodi k razgradnji pozobnice, cementa in kosti zobiščnega odrastka, nastanku obzobnih žepov in izgubi zob. Trenutne smernice zdravljenja pogosto ne vodijo k želenim rezultatom, zato so aktualne raziskave novih terapevtskih pristopov in zdravil. V prispevku predstavljamo različne možnosti zdravljenja, kot so (I) zmanjšanje števila pa- togenih bakterij in vzpostavitev normalne ustne flore, (II) moduliranje imunskega odziva in (III) iz- boljšanje obnove poškodovanega tkiva, predvsem z dostavo ustreznih učinkovin v obliki nanozdravil, kot so liposomi, nanodelci in nanovlakna. Z nanozdravili lahko dosežemo daljše zadrževanje in prirejeno sproščanje učinkovin na tarčnem mestu, z nanovlakni pa lahko tudi pospešimo obnovo prizadetega obzobnega tkiva"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-7UVU3XBH","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-7UVU3XBH"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-7UVU3XBH/6cf93b5f-b0ce-48cd-8343-757648a8bd33/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-7UVU3XBH/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-7UVU3XBH"}}}}