206 KB31 KB199420252010Jančar, NinaVrtačnik-Bokal, Edaštevilka:3letnik:49str. 275-284ISSN:0025-8121COBISSID:27442393URN:URN:NBN:SI:doc-5RIFBUTGslMedicinski razglediMedicinski razglediginekologijamaternični vratonkologijapapiloma virusipredrakave spremembepreventivna medicinarak (medicina)Predrakave spremembe materničnega vratu| Cervical precancerous lesions|Cervical cancer evolves through several stages of precancerous lesions and can therefore be prevented by me ans of organized screening program and effective treatment of precancerous lesions. Persistent infection with high-risk or oncogenic human papillomavirus genotypes has been accepted as thesingle necessary etiological factor for cervical precancerous lesions and cervi cal cancer. Histologicaly we divide cervical squamous cel1 precancerous lesions into three grad es; cervi cal intraepithelial neoplasia of first grade, second grade and third grade. Cervical adenocarcinoma evolves through precancerous lesions of malignantly transformed glandular cel1s. Cervical precancerous lesions can be prevented by means of limiting sexual1y transmitted infection with high-risk human papillomavirus genotypes. Prophylactic vaccination against two most commonly encountered human papillomavirus genotypes, 16 and 18, has been introduced recently. Slovenian Guidelines for management ofwomen with cervical precancerous lesions are summarized in the manuscriptTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi