859 KB30 KB200520252023Dolšak, AnaSova, Matejštevilka:3letnik:74str. 197-204ISSN:0014-8229COBISSID_HOST:160755459URN:URN:NBN:SI:doc-5NDBZBPVslSlovensko farmacevtsko društvoFarmacevtski vestnikbolezenska stanjaMetabolizemPrehranska dopolnilaterapevtska uporabatriptofanTriptofan in njegova vloga v človeškem organizmu| Tryptophan and its role in the human body|Tryptophan represents one of the 20 amino acids for humans and is consumed through a balanced diet. In addition to its structural role as a building block of proteins it serves as a precursor to many biologically active molecules, indirectly influences sleep and wellbeing, and plays an important role in regulating the immune system. Deficiency occurs very rarely; however, it could be used as a dietary supplement to improve mood and sleep quality. Metabolism occurs through the serotonin or kynurenine pathway, and the resulting metabolites may be involved in various diseases, such as cancer, autoimmune diseases, inflammation and infections. Therefore, the enzymes involved in tryptophan metabolism represent potential targets for the development of new drugsTriptofan predstavlja eno izmed 20 aminokislin pri človeku, ki jo pridobimo z uravnoteženo prehrano. Poleg strukturne vloge gradnika proteinov služi kot prekurzor številnih biološko aktivnih molekul. Posredno vpliva na spanje in počutje ter ima pomembno posredno vlogo pri uravnavanju imunskega sistema. Do pomanjkanja triptofana pride zelo redko. V obliki prehranskega dopolnila ga lahko uporabljamo za izboljšanje razpoloženja in kakovosti spanja. Presnova poteka po serotoninski ali kinureninski poti, nastali metaboliti pa so lahko vpleteni v različna bolezenska stanja, kot so rak, avtoimunske bolezni, vnetja in infekcije. Encimi, udeleženi v metabolizem triptofana, zato predstavljajo potencialne tarče za razvoj novih učinkovinTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo