3771 KB19 KB199220251998Rogl-Butina, Mirjamštevilka:3/4letnik:7str. 139-144ISSN:1318-4458COBISSID:8099545URN:URN:NBN:SI:doc-460HXATPenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaAdministration, oralAdverse effectsAntifungal agentsCytochrome p-450dermatologijaDrug effectsDrug interactionsDrug therapyFluconazoleGriseofulvinItraconazolekožne bolezniLivermikozeMycosesstranski učinkiToxicityzdravljenjeSide effects of systemic antimycotic treatment|Fungal infections are common in humans and their prevalence is still growing. Most mycotic infections of skin, mucosae and their appendages are very appropriate for topical treatment, but for certain clinical manifestations (onychomycosis, tinea capitis, chronically recidivating vaginal infections andextensive or very resistant glabrous skin infections, especially in immunocompromized patients) systemic antimycotic therapy seems to be the reasonable choice. The mechanisms of action of oral antifungals that are currently most often prescribed in Slovenia and their most common side effectsare discussed: adverse events, asymptomatic elevations of liver function tests, symptomatic liver injury, side effects connected with cytochrome P450 and drug interactions. Finally we describe the recommendationsabout oral antimycotics during pregnancy and lactation and their possible interference with the activity of oral contraceptivesTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov