48178 KB0 KB199220252025Batistella, MelaniaKopytina, ValeriaLópez Berroa, JorgeLópez Berroa, JorgeMaan, ClaudiaOliveira, SandraSantaella, Erickletnik:34številka:iss. 2str. 65-72DOI:10.15570/actaapa.2025.16ISSN:1318-4458COBISSID_HOST:260269827URN:URN:NBN:SI:doc-43V05T75enSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et Adriaticaatrofične brazgotine po aknahcollagenasekolagenezaliazalyasemicroneedlingmikroiglanjepost-acne atrophic scarsPbserum Specific Acne Scars®| a cutting-edge approach utilizing triple enzymatic synergy combined with microneedling for post-acne scar repair|Introduction: The integration of active ingredients into scientifically backed formulations is an innovative approach to remodeling post-acne atrophic scars, stimulating regenerative processes. Microneedling, a minimally invasive procedure, promotes collagen production and enhances skin penetration of cosmeceutical products such as Pbserum Specific Acne Scars®, which combines collagenases G and H with hyaluronate r-lyase and other ingredients, including allantoin, zinc sulfate, vitamin A, vitamin B3, niacinamide, and melatonin. These components modulate inflammation, fibrosis, oxidative stress, and aging. This study assesses the efficacy and safety of treatment for ameliorating atrophic acne scars. Methods: Twenty-nine patients were treated with Pbserum Specific Acne Scars® applied by microneedling for 4 months in four sessions on the middle or lower third of the face and/or periocular area. The scar size (according to EvaFace® analysis), deep skin hydration (measured with a Moisturemeter® D device), severity (assessed using the échelle d’évaluation clinique des cicatrices d’acne and Goodman and Baron scales), clinical efficacy (evaluated using Global Aesthetic Improvement Scale), quality of life (measured using Facial Acne Scar Quality of Life questionnaire), and subject satisfaction were analyzed. Results: Significant improvements were observed in all parameters evaluated, especially after four applications, demonstrating clinical efficacy. Patient satisfaction levels were notably high. Conclusions: The treatment significantly improved skin texture and scar appearance after four applications over a period of 4 monthsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov