{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-3LBR8K30/3f47ffd6-4e19-41f8-b787-8cdcb24508af/HTML","dcterms:extent":"27 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-3LBR8K30/bab1f398-0362-4518-bb6e-be25962c62f5/PDF","dcterms:extent":"385 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-3LBR8K30/b88c620b-2b90-476d-b476-92eec0f8fe38/TEXT","dcterms:extent":"26 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-3LBR8K30","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2007","dc:creator":["Čelhar, Teja","Ferk, Polonca","Mlinarič-Raščan, Irena"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:58"},{"@xml:lang":"sl","#text":"6 strani"},{"@xml:lang":"sl","#text":"str. 149-154"}],"dc:identifier":["ISSN:0014-8229","COBISSID:2229105","URN:URN:NBN:SI:doc-3LBR8K30"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"biološki označevalci"},{"@xml:lang":"sl","#text":"farmakogenetika"},{"@xml:lang":"sl","#text":"farmakogenomika"},{"@xml:lang":"sl","#text":"genetska raznolikost"},{"@xml:lang":"sl","#text":"genetski polimorfizem"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"Genetska raznolikost kot osnova uporabnosti farmakogenomike v klinični praksi|"},"dc:description":[{"@xml:lang":"sl","#text":"The article focuses on the findings regarding genetic variability between individuals as the basis for pharmacogenomic studies. Each genetic variant mayrepresent a potential biomarker for the determination of susceptibility fora particular disease, for early diagnostics, prediction of further development or regression of disease and for the selection of the most appropriate therapy. Some genetic polymorphisms have become useful biomarkers for the optimization and individualization of pharmacotherapy in clinical practice, predominately for the reduction of severe adverse reactions and the selection of patients, who are most likely to respond to targeted anticancer therapy"},{"@xml:lang":"sl","#text":"V prispevku predstavljamo najnovejse podatke o genetski raznolikosti med posamezniki kot osnovo za farmakogenomske otudije. Vsaka genetska razlieica jenamree potencialni biolosi oznaeevalec za ugotavljanje nagnjenosti k doloeeni bolezni, za zgodnje diagnosticiranje, napoved poteka bolezni in za izbiro primernega zdravljenja. Nekateri genetski polimorfizmi se kot bioloski oznaeevalci za optimizacijo in individualizacijo farmakoterapije ae uporabljajo v klinieni praksi. Navedli smo nekaj primerov tovrstnih oznaeevalcev, ki se trenutno doloeajo z namenom zmanjsevanja stranskih ueinkovzdravljenja ter za prepoznavanje bolnikov, ki se bodo odzvali na ciljano zdravljenje s protitumorskim zdravilom"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-3LBR8K30","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-3LBR8K30"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-3LBR8K30/bab1f398-0362-4518-bb6e-be25962c62f5/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-3LBR8K30/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-3LBR8K30"}}}}