1483 KB31 KB200520252024Grobin, AndrejRoškar, RobertTrontelj, Jurijštevilka:2letnik:75str. 75-82ISSN:0014-8229COBISSID_HOST:196279555URN:URN:NBN:SI:doc-3D1XIN3FslSlovensko farmacevtsko društvoFarmacevtski vestnikčistilne napraveendocrine disruptorsHormonski motilcikemični motilci endokrinega sistemaocena tveganjaPovršinske voderisk assessmentsurface waterwastewater treatment plantsOcena obremenitve slovenskih vod s hormoni in izbranimi hormonskimi motilci| Assessment of slovenian waters’ burden with hormones and selected endocrine disruptors|Hormones and some active pharmaceutical ingredients can act as endocrine disruptors (EDs) in the environment, which can have serious effects on aquatic organisms and humans. Due to insufficient data on their occurrence and risks, we developed and validated an ultra-sensitive analytical method for quantitative determination of the occurrence of 25 different EDs. With it, we analyzed 36 wastewater and 33 river water samples and successfully quantified 16 EDs, with the highest concentrations of bisphenols (BPs) S, A and F, estriol and chlormadinone, and with concentrations above safe levels for estradiol and ethinyl estradiol. We determined that wastewater treatment plants are generally successful in the removal of most EDs but are currently overburdened. The presence of BPA, estradiol, BPS and estrone represents high risk in the majority, and the presence of synthetic steroids in a tenth of the river water samples, with the safe limits exceeded by two orders of magnitude in several samplesHormoni in nekatere zdravilne učinkovine v okolju delujejo kot kemični motilci endokrinega sistema (KMES), ki imajo lahko resne učinke na vodne organizme in človeka. Zaradi pomanjkljivih podatkov o njihovi pojavnosti in tveganjih smo razvili in validirali ultra občutljivo analizno metodo za kvantitativno določanje prisotnosti 25 različnih KMES. Z njo smo analizirali 36 vzorcev odpadnih in 33 rečnih vod in pri tem uspešno kvantificirali 16 KMES, z najvišjimi koncentracijami bisfenolov (BP) S, A in F, estriola in klormadinona ter koncentracijami nad varnimi za estradiol in etinil estradiol. Določili smo, da so čistilne naprave v splošnem uspešne pri odstranjevanju večine KMES, a so trenutno preobremenjene. Prisotnost BPA, estradiola, BPS in estrona predstavlja veliko tveganje v večini, prisotnost sinteznih steroidov pa v desetini vzorcev rečnih vod, pri čemer so varne meje v več vzorcih presežene tudi za dva velikostna razredaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo