{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-32LLXM7D/05f4ed3e-007a-4923-b1a2-14b3be48ab53/PDF","dcterms:extent":"464 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-32LLXM7D/153481ac-24cd-4b60-9705-cc8de0e1acb0/TEXT","dcterms:extent":"67 KB"}],"edm:TimeSpan":{"@rdf:about":"1998-2025","edm:begin":{"@xml:lang":"en","#text":"1998"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-32LLXM7D","edm:isNextInSequence":{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:doc-C5BCYUH8"},"dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-KC6O72BG"},{"@xml:lang":"sl","#text":"Acta chimica slovenica"}],"dcterms:issued":"2012","dc:creator":["Peterlin-Mašič, Lucija","Schmidt, Jan"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:59"},{"@xml:lang":"sl","#text":"str. 722-738"}],"dc:identifier":["ISSN:1318-0207","COBISSID:3368561","URN:URN:NBN:SI:doc-32LLXM7D"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"dc:subject":[{"@xml:lang":"en","#text":"aryl hydrocarbon receptor (AhR)"},{"@xml:lang":"en","#text":"endocrine disrupting compounds (EDCs)"},{"@xml:lang":"sl","#text":"endokrini hormoni"},{"@xml:lang":"sl","#text":"endokrini motilci"},{"@xml:lang":"en","#text":"estrogen receptors (ERs)"},{"@xml:lang":"sl","#text":"estrogenski receptorji"},{"@xml:lang":"en","#text":"reactive metabolites"},{"@xml:lang":"sl","#text":"reaktivni metaboliti"}],"dcterms:temporal":{"@rdf:resource":"1998-2025"},"dc:title":{"@xml:lang":"sl","#text":"Organic synthetic environmental endocrine disruptors: structural classes and metabolic fate|"},"dc:description":[{"@xml:lang":"sl","#text":"Endocrine disruption is the modification of the endocrine system causing harmful effects in healthy subjects or their offspring. Physiological endocrine hormones act at very low plasma concentrations, and certain chemicals known as endocrine disrupting compounds (EDCs) are suspected of modifying endocrine function at similarly low concentrations. In our review we focus mainly on the structural classes of organic synthetic environmental endocrine disruptors and their common structural elements that enable them to interact with estrogen signalling. EDCs can affect estrogenic signalling directly through interaction with estrogen receptors (ERs) or indirectly through transcription factors such as the aryl hydrocarbon receptor (AhR) or by modulation of critical metabolic enzymes engaged in estrogen biosynthesis and metabolism. However, some structural elements can also pose a great risk of cytotoxicity and genotoxicity, especially after biotransformation to reactive metabolites"},{"@xml:lang":"sl","#text":"Motnje endokrinega sistema pomenijo tiste spremembe v delovanju endokrinega sistema, ki povzročijo škodljive učinki pri zdravih ljudeh ali njihovih potomcih. Fiziološki endokrini hormoni delujejo v zelo nizkih plazemskih koncentracijah, medtem ko se za določene kemijske spojine, poznane kot endokrini motilci (EDCs), prav tako predvideva sprememba endokrine funkcije pri podobno nizkih koncentracijah. V preglednem članku smo se osredotočili predvsem na pregled strukturnih razredov organskih sinteznih okoljskih endokrinih motilcev ter na njihove skupne strukturne elemente, ki jim omogočajo interakcijo z estrogenim signaliziranjem. Endokrini motilci lahko vplivajo na estrogeno signaliziranje neposredno preko interakcije z estrogenimi receptorji (ERs) ali posredno preko transkripcijskih faktorjev kot je receptor za aromatske ogljikovodike (AhR) ali preko modulacije kritičnih encimov, ki sodelujejo pri biosintezi in presnovi estrogenov. Nekateri strukturni elementi hormonskih motilcev predstavljajo tveganje za citotoksično in genotoksično delovanje, predvsem preko bioaktivacije v reaktivne metabolite"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-32LLXM7D","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-32LLXM7D"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-32LLXM7D/05f4ed3e-007a-4923-b1a2-14b3be48ab53/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-32LLXM7D/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-32LLXM7D"}}}}