34 KB151 KB30 KB200520252009Brunskole Švegelj, MojcaLanišnik-Rižner, TeaStojan, Jureštevilka:36 straniletnik:60str. 159-164ISSN:0014-8229COBISSID:25713625URN:URN:NBN:SI:doc-2YCZ3DHJslSlovensko farmacevtsko društvoFarmacevtski vestnikdehidrogenazeencimihormonimetabolizemreduktazeEncimi iz naddružine kratkoverižnih dehidrogenaz/reduktaz kot nove farmakološke tarče| Enzymes of the short-chain dehydrogenase/reductase superfamily s new pharmacological targets|Short-chain dehydrogenases/reductases (SDR) constitute a large protein family.Although they have several structural features in common, they act on ahighly diverse set of substrates. They are involved in metabolism of steroid hormones, fatty acids, alcohols, retinoids, prostaglandins and xenobiotics. Around 70 SDR members are identified within the human genome. In human body they participate in numerous distinct (patho)physiological processes, thus they are very interesting therapeutic targets for the treatment of genetic, hormone dependent and metabolic diseases like galactosemia, phenylketonuria, breast cancer, endometrium, prostate and colon cancer, dyslipidemia, obesity and arterial hypertensionTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo