28 KB148 KB26 KB200520252008Brunskole Švegelj, MojcaLanišnik-Rižner, TeaStojan, Jureštevilka:15 straniletnik:59str. 21-25ISSN:0014-8229COBISSID:24067545URN:URN:NBN:SI:doc-1GR9WFM9slSlovensko farmacevtsko društvoFarmacevtski vestnikAntifungal AgentsAntimikotikiBiosynthesisDermatomikozeDermatomycosesEnzymologyFungifungusGliveMelaniniMelaninsVirulencaVirulenceEncimi vključeni v biosintezo glivnega melanina - potencialne tarče za razvoj novih antimikotikov| Enzymes involved in fungal melanin biosynthesis - potential targets for the development of new antimicotic drugs|Dematiaceous or dark-pigmented fungi are responsible for many infections, and especially in immunocompromised patients. Thesefungi contain melanin in their cell walls that protects them from environmental stresses and is considered tobe an important virulence factor.Infections caused by dematiaceous fungi include phaeohyphomycosis, chromoblastomyciosis and mycetoma. Despite combinedantimicotic therapies, these infections can still result in high overall mortality rates and represent an important health issue. We present here the 1,8-dihydroxynaphthalene melanin biosynthetic pathway and the enzymesinvolved. As 1,8-dihydroxynaphthalene melanin appears only in fungi, the enzymes involved in its biosynthesis represent interesting targets for thedevelopment of new selective antimicoticsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo