6287 KB19 KB199220251996Hödl, S...Müllegger, R... R.Soyer, H... P.številka:3-4letnik:5str. 123-129ISSN:1318-4458COBISSID_HOST:5108441URN:URN:NBN:SI:doc-180OC15QenSlovene Welding SocietyActa dermatovenerologica Alpina, Pannonica et AdriaticaAcrodermatitisDiagnosisErythema chronicum migransEtiologyHistological techniquesLyme diseasePathologyScleroderma, circumscribedDermatopathologic diagnosis of lyme borreliosis|The goal of this study was to determine the general light microscopic findings which lend support to the histopathologic diagnosis of the main cutaneous manifestations of Lyme Borreliosis. Their diagnostic criteria are delineated and illustrated. In culminating lesions of erythema migrans and acrodermatitis chronica atrophicans, a peculiar connective tissue reaction includes an increase in the number of fibroblasts, proliferation of collagen fibers, and interstitial mucinous edema. The cellular infiltrates are patchy perivascular in erythema migrans and either patchy and/or band-like in acrodermatitis chronica atrophicans. They consist of lymphohistiocytic cells with a variable admixture of plasma cells. The damage to elastic (and even collagen) fibers occurs in early acrodermatitis chronica atrophicans and is reflected by the phenomenon of elastophagocytosis. Reducation or lack of pilosebaceous units is a constant finding. In advanced lesions of acrodermatitis chronica atrophicans, a thinning of the dermal breadth is noticed, resulting from a decrease in collagen and elastic fibers. Fibrous nodulus and morphea-like conditions are characterized by excessive formation of collagen. Borrelial lymphocytoma exhibits two different patterns of infiltration, accompanied by dermal fibrosis and increased numbers of fibroblasts. Recent tick bites show a predominantly neutrophilic infiltrate. By applying the results of this synoptic study, histopathologic diagnosis of dermatoborrelioses should be possible without the absolute necessity of clinical correlationTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaZdruženje slovenskih dermatovenerologov