{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-0IC3GSZQ/37ff7d08-1f0d-4953-8c88-4f2998e00faa/HTML","dcterms:extent":"22 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-0IC3GSZQ/f39fc54e-dd2a-4980-a5c6-4c07c9faae8f/PDF","dcterms:extent":"105 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:doc-0IC3GSZQ/66c1161a-478c-437c-ab09-d9476159d031/TEXT","dcterms:extent":"21 KB"}],"edm:TimeSpan":{"@rdf:about":"2005-2025","edm:begin":{"@xml:lang":"en","#text":"2005"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:doc-0IC3GSZQ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-8ER5ZBJN"},{"@xml:lang":"sl","#text":"Farmacevtski vestnik"}],"dcterms:issued":"2011","dc:creator":["Trdan Lušin, Tina","Trontelj, Jurij"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:62"},{"@xml:lang":"sl","#text":"str. 171-174"}],"dc:identifier":["ISSN:0014-8229","COBISSID:3133041","URN:URN:NBN:SI:doc-0IC3GSZQ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"eksperimentalni modeli"},{"@xml:lang":"sl","#text":"in vitro modeli"},{"@xml:lang":"sl","#text":"metabolizem"},{"@xml:lang":"sl","#text":"subcelične frakcije"},{"@xml:lang":"sl","#text":"zdravilne učinkovine"}],"dcterms:temporal":{"@rdf:resource":"2005-2025"},"dc:title":{"@xml:lang":"sl","#text":"In vitro modeli za preučevanje metabolizma učinkovin v jetrih| In vitro models for investigation of drug metabolism in the liver|"},"dc:description":[{"@xml:lang":"sl","#text":"This article gives a systematic review of in vitro experimental models for hepatic drug metabolism. The presented models include: recombinant enzymes, microsomes, cytosol, S9 fraction, isolated hepatocytes, cell lines, liver tissue slices and perfused liver. For each model, a comprehensive overview is given, including application, benefits, and drawbacks"},{"@xml:lang":"sl","#text":"V prispevku so sistematično predstavljeni eksperimentalni modeli za preučevanje jetrnega metabolizma učinkovin in vitro. Opisani so naslednji modeli po rastoči stopnji kompleksnosti: rekombinantni encimi, mikrosomi, citosol, S9 frakcija, izolirani hepatociti, celične linije, jetrne rezine in perfundirana jetra. Predstavljene so njihove prednosti, slabosti in omejitve ter področja uporabe"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:doc-0IC3GSZQ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:doc-0IC3GSZQ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:doc-0IC3GSZQ/f39fc54e-dd2a-4980-a5c6-4c07c9faae8f/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko farmacevtsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:doc-0IC3GSZQ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:doc-0IC3GSZQ"}}}}