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II-59-II-63"}],"dc:identifier":["ISSN:1318-0347","COBISSID:24289497","URN:URN:NBN:SI:doc-ZK60MQR0"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"baby"},{"@xml:lang":"en","#text":"Cognition Disorders"},{"@xml:lang":"sl","#text":"Dojenček"},{"@xml:lang":"sl","#text":"Epilepsija"},{"@xml:lang":"en","#text":"Epilepsy"},{"@xml:lang":"en","#text":"Infant"},{"@xml:lang":"en","#text":"Spasms, Infantile"},{"@xml:lang":"sl","#text":"Spazmi infantilni"},{"@xml:lang":"sl","#text":"Spoznavne motnje"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Brain growth, mental and cognitive development can be influenced by severe epileptic activity during early infancy| Huda epileptična aktivnost - hipsaritmija - lahko vpliva na rast možganov, umski in kognitivni razvoj v ranem otroštvu|"},"dc:description":[{"@xml:lang":"sl","#text":"Infantile spasms belong to epileptic encephalopathies of early infancy and represent one of the major causes for acquired mental retardation in early childhood. Cognitive and behaviour impairments can be present even after benign course of disease. Cognitive deficits are in correlation with treatmentlag longer then one month, the risk of mental retardation increases after three weeks of hypsarrhythmia duration. Recent studies demonstrate a negative influence of epileptic activity on cortical development in critical period of early brain development. Early treatment is associated with favourable prognosis in cryptogenic as in some symptomatic infantile spasms; however, to prevent specific cognitive deficits early therapeutic strategies should be considered"},{"@xml:lang":"sl","#text":"Infantilne spazme uvrščamo med epileptične encefalopatije dojenčka in kot epileptični sindrom predstavljajo enega glavnih vzrokov pridobljene umske manjrazvitosti zgodnje otroške dobe. Kognitivni in vedenjski primanjkljaji so lahko prisotni tudi pri benignem poteku bolezni. Kognitivni primanjkljaji so vpovezavi s zamikom začetka zdravljenja, daljšem od enega meseca od začetka spazmov, tveganje za umsko manjrazvitost pri bolniku pa se poveča že po treh tednih trajanja hipsaritmije. Novejše raziskave potrjujejo negativni vpliv epileptične aktivnosti na razvoj možganske skorje v kritičnem časovnem obdobjuzgodnje razvojne faze možganov. Pravočasno zdravljenje je povezano z ugodnejšo prognozo pri kriptogenih kot tudi pri nekaterih simptomatskih infantilnih spazmih; smiselno pa bi bilo razmisliti tudi o uvedbi zgodnjih terapevtskih strategij za preprečevanje specifičnih kognitivnih primanjkljajev"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-ZK60MQR0","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-ZK60MQR0"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-ZK60MQR0/ad5aaa09-5e95-459a-ae2c-74df25f5e19a/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-ZK60MQR0/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-ZK60MQR0"}}}}