{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-YJC6IHBK/d2136a35-aff9-4aa2-b680-8dad9a3a3921/PDF","dcterms:extent":"136 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-YJC6IHBK/e621b69a-3733-40f1-b7e4-ef40f348d9f8/TEXT","dcterms:extent":"8 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-YJC6IHBK","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"1997","dc:creator":["Ardizzoia, A...","Colombo, A...","Crispino, Sergio","Gambaro, G...","Ghezzi, P...","Krengli, M...","Lastrucci, L...","Parmigiani, F...","Ponticelli, P...","Ribecco, A...","Simeone, F...","Taino, R..."],"dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:31"},{"@xml:lang":"sl","#text":"str. 202-204"}],"dc:identifier":["ISSN:1318-2099","COBISSID_HOST:7177945","URN:URN:NBN:SI:doc-YJC6IHBK"],"dc:language":"en","dc:publisher":[{"@xml:lang":"sl","#text":"Croatian Medical Association - Croatian Society of Radiology"},{"@xml:lang":"sl","#text":"Slovenian Medical Society - Section of Radiology"}],"dc:subject":[{"@xml:lang":"sl","#text":"Drug therapy"},{"@xml:lang":"sl","#text":"Laryngeal neoplasms"},{"@xml:lang":"sl","#text":"Laryngectomy"},{"@xml:lang":"sl","#text":"Radiotherapy"},{"@xml:lang":"sl","#text":"Treatment outcome"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Concomitant radio-chemotherapy for larynx preservation|"},"dc:description":{"@xml:lang":"sl","#text":"Background: A pilot multicentric study of concomitant radio-chemotherapy was performed to evaluate the feasibility, the toxicity and larynx preservation rate in patients with previously untreated, resectable laryngo-pharyngeal squamous cell carcinoma, otherwise requiring laryngectomy +- pharyngectomy. Materials and methods. Forty-two patients entered the study: radiotherapy was planned to a tumour dose of 70 Gy and chemotherapy was applied concomitantly, consisting of Cisplatinum and 5-Fluorouracil (bolus) or Carboplatinum and 5-Fluorouracil (continuous infusion) combination repeated every 3 weeks. In all but complete responders laryngestomy +- pharyngectomy and/or neck dissection was performed for residual disease. Results: Toxicity was mild and no drug related deaths occurred. Complete response rate was 81% and, after salvage surgery, 93% of patients were considered disease free. After a median follow-up of 38 months, 53% of patients were alive and of these 88% with larynx preserved. Conclusion: Concomitant radiochemotherapy seems to be a feasible strategy with acceptable toxicity for patients with laryngo-pharyngeal squamous cell carcinoma, otherwise eligible for total laryngectomy"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-YJC6IHBK","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-YJC6IHBK"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-YJC6IHBK/d2136a35-aff9-4aa2-b680-8dad9a3a3921/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Onkološki inštitut Ljubljana"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-YJC6IHBK/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-YJC6IHBK"}}}}