22 KB117 KB19 KB200520252006Dragoš, Vlasta4 straniletnik:63str. 96-99ISSN:0014-8229COBISSID:21457369URN:URN:NBN:SI:doc-YH1GU2OTslSlovensko farmacevtsko društvoFarmacevtski vestnikAdministration, TopicalAdrenal Cortex HormonesdermatitisDermatitis atopičniDermatitis, AtopicDiagnosisDrug TherapyKortikosteroidiTacrolimusTakrolimustherapyZdravilo, lokalna uporabazdravljenjeAtopijski dermatitis - sodobno zdravljenje|Atopic dermatitis is very common skin disorder in well developed countries. Pruritic skin lesions appear on different sites of predilection in different age groups. The appearance of skin leisons are changed by superinfectons casedby bacteria or viruses. Topical steroids have been the conventional therapy for atopic dermatitis for 50 years. They act on broad spectrum of immune cells but also interfere with other skin cells. Tacrolimus ointment andpimecrolimus cream are new topically effective macrolides. Both were found safe and effective for the treatment of atopic dermatitis in children and adults. They inhibit inflammatory cytokines transcription and other inflammatory cells through inhibition of calcineurin. Local risk of corticosteroids do not occur, nor do the systemic side effects. When used in the first signs and symptoms of the disease they have significant advantages over conventional therapy and steroid sparing effect. Key words: atopic dermatitis, current topical treatment, pimecrolimus, tacrolimusTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko farmacevtsko društvo