{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-XM1EGSIJ/8ff3e2ce-0936-432e-b37f-7614b4e65b93/HTML","dcterms:extent":"37 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-XM1EGSIJ/2dc27e0a-fe03-4f5b-b153-9a2de93a64e3/PDF","dcterms:extent":"88 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-XM1EGSIJ/2ba91971-1072-4552-91a9-5df824a16aaf/TEXT","dcterms:extent":"34 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-XM1EGSIJ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2006","dc:creator":["Kmet Lunaček, Nina","Možina, Hugon","Pernat, Andrej"],"dc:format":[{"@xml:lang":"sl","#text":"letnik:75"},{"@xml:lang":"sl","#text":"številka:9"},{"@xml:lang":"sl","#text":"str. 567-573"}],"dc:identifier":["ISSN:1318-0347","COBISSID:21821145","URN:URN:NBN:SI:doc-XM1EGSIJ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"Atrial Natriuretic Factor"},{"@xml:lang":"en","#text":"cardiovascular disease"},{"@xml:lang":"en","#text":"diagnostika"},{"@xml:lang":"en","#text":"Echocardiography"},{"@xml:lang":"sl","#text":"Ehokardiografija"},{"@xml:lang":"sl","#text":"kardiovaskularne bolezni"},{"@xml:lang":"sl","#text":"Mioglobin"},{"@xml:lang":"en","#text":"Myoglobin"},{"@xml:lang":"en","#text":"Natriuretic Hormone"},{"@xml:lang":"sl","#text":"Natriuretični hormon"},{"@xml:lang":"sl","#text":"Pljučna embolija"},{"@xml:lang":"sl","#text":"Preddvorni, natriuretični faktor"},{"@xml:lang":"en","#text":"Prognosis"},{"@xml:lang":"sl","#text":"prognostični dejavniki"},{"@xml:lang":"sl","#text":"Prognoza"},{"@xml:lang":"en","#text":"Pulmonary Embolism"},{"@xml:lang":"sl","#text":"Srce, prekat desni, disfunkcija"},{"@xml:lang":"sl","#text":"srčni prekat"},{"@xml:lang":"en","#text":"Troponin"},{"@xml:lang":"en","#text":"Ventricular Dysfunction, Right"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Prognostični pomen srčnih biomarkerjev pri bolnikih s pljučno trombembolijo| Cardiac biomarkers in prognostic stratification of patients with pulmonary thrombembolism|"},"dc:description":[{"@xml:lang":"sl","#text":"Background Pulmonary thrombembolism represents a spectrum of clinical syndromes ranging from small embolism presenting with dyspnea alone to massivethrombembolism causing shock or cardiac arrest. Majority of patients with pulmonary thrombembolism present with normal blood pressure, however, some may rapidly deteriorate despite therapeutic anticoagulation with heparine. Identification of such patients by risk stratification is of utmost importance for the care of pulmonary thrombembolism. It has been known for several years that a strong corellation exists between the prognosis of acute pulmonary thrombembolism and the degree of right ventricular dysfunction. Recently, some cardiac biomarkers have shown to be a promising predictive factor in evaluating right ventricular dysfunction and consequently establishing the prognosis of the clinical course in submassive and massive pulmonary thrombembolism. In the article the most important recent studies arerepresented confirming the important role of cardiac biomarkers in connection with prognosis in acute pulmonary thrombembolism. The most important are troponins, B-type of natriuretic peptide (BNP) with its pro-types and myoglobin. Conclusions Elevated levels of troponins, in combination with echocardiographic signs of right ventricular dysfunction, arepowerful predictors of adverse events and early mortality in normotensive patients with pulmonary thrombembolism. Normal or only slightly elevated levels of brain natriuretic peptides identify favourable prognosis in patientswith pulmonary thrombembolism"},{"@xml:lang":"sl","#text":"Izhodišča Pljučna trombembolija je spekter kliničnih sindromov, od blage oblike, ki se kaže zgolj s težko sago, pa vse do masivne trombembolije z znakišoka ali celo zastoja srca. Večina bolnikov s pljučno trombemboljo je hemodinamsko neprizadeta, vendar se pri delu teh bolnikov stanje navkljub zdravljenju s heparinom lahko poslabša. Zato je zelo pomembno s pomočjo napovednikov poskušati določiti, kateri so ti bolniki. Že več let je znano, danapoved izida bolnikov z akutno pljučno trombembolijo korelira s stopnjo odpovedi desnega prekata, ki jo določimo s pomočjo ultrazvočne preiskave. V zadnjih letih pa so se srčni biomarkerji izkazali kot obetajoč napovedni dejavnik pri opredejevanju prisotnosti disfunkcije desnega prekata in posledično napovedi poteka masivnih in submasivnih pljučnih trombembolij. V prispevku so predstavljene najpomembnejše raziskave, opravljene v zadnjih letih, ki so umestile vlogo srčnih biomarkerjev kot kazalcev prisotnosti disfunkcije desnega prekata. Najpomembnejši so troponini, B-podtip natriuretičnega peptida (BNP) s prohormonskimi oblikami ter mioglobin. Zaključki Predvsem povečane vrednosti troponina v kombinaciji z ultrazvočnimi znaki odpovedovanja desnega prekata opredelijo tiste bolnike s pljučno trombembolijo, ki imajo kljub hemodinamski neprizadetosti povečano tveganje zanenadno poslabšanje in smrt. Normalne ali blago povečane vrednosti natriuretičnih peptidov opredelijo predvsem bolnike, ki imajo nezapleten potek"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-XM1EGSIJ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-XM1EGSIJ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-XM1EGSIJ/2dc27e0a-fe03-4f5b-b153-9a2de93a64e3/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-XM1EGSIJ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-XM1EGSIJ"}}}}