51 KB121 KB45 KB192920262001Kržan, Mojcaštevilka:10letnik:70str. 553-559ISSN:1318-0347COBISSID:14052569URN:URN:NBN:SI:doc-TYBIUSQTslSlovensko zdravniško društvoZdravniški vestnikAge factorsAstrocitiAstrocytesBrain injuriesCentral nervous system diseasesCentralno živčevje, bolezniGestacijska starostGestational ageGliosisGliozaMožgani, poškodbeNerve growth factorsosrednje živčevjeStarostni faktorjiživčevježivčne celiceŽivec, rastni faktorjiFunkcija astrocitov| Astrocytes' function|Background. Although astrocytes represent 50 of cells in the central nervous system they were recognized as passive, supportive cells regulating homeostasis and creating the microenvironment suitable for neuronal cells to function. Butlately, it was proven that astrocytes possess a unique feature - they are capable of changing their morphology and function throughout life in response to changes in brain microenvironment. Conclusions. They have important functions during development, adulthood and after the brain injury, when they actively participate in the regeneration process or form a scar after excessive neuron loss. Recently discovered functions of astrocytes are: equal partnership in tripartite synapse and active regulation of generation and maintenance of synapses in central nervous systemIzhodišča: Kjub temu da astrociti predstavljajo 50% celic v osrednjem živčevju, so jim dalgo časa pripisovali le pasivno podporno funkcijo, ki poskrbi za homeostazo in vydrževanje primernega mikrookolja za delovanje nevronov. Zaključki. Izkazalo se je, da imajo astrociti edinstveno vlogo, ker lahko med življenjem spreminjajo svojo obliko in funkcijo in imajo popolnoma različno vlogo med razvojem in v odraslem abdobju ter aktivno pasegajo v dogodke ob možganski poškodbi in regeneraciji. Nedavno odkriti funkciji astrocitov sta, da so astrociti enakopraven član tridelne sinapse in da regulirajo tvorbo in vzdrževanje sinapsTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo