19 KB115 KB19 KB200220262006Fatur, TanjaHočevar-Grom, AdaPerharič, Lucijaštevilka:4letnik:455 stranistr. 186-190ISSN:0351-0026COBISSID:1716197URN:URN:NBN:SI:doc-TLAQ6TB3slInštitut za varovanje zdravja Republike SlovenijeZdravstveno varstvoDNKgenotoksičnostmutagenipesticidipitna vodaškodljivostGenotoksičnost pesticidov, vključenih v spremljanje stanja pitne vode v Sloveniji| Genotoxicity of pesticides involved in monitoring of drinking water in Slovenia|Pesticides used to supress plant disease and control pest may affect human health. One of the adverse health affects of pesticides is their genotoxic activity, which leads to permanent changes in deoxyribonucleic acid (DNA), i.e. the so-called mutations. Mutations formed in somatic cells may result in cancer, and those in germ cells can be transmitted to the offspring. They can trigger processess involved in the development of genetically transmitted disease or may cause abortion. The genotoxic potential of pesticides is evaluated by a battery of assays. Drinking water in Slovenia is monitored for the presence of 55 pesticides. The results hitherto obtained for 23 pesticidesshowed no genotoxic potential. Genotoxicity is also assessed for some pesticide metabolites, formed in organisms or in the environment. Very little is known, however, about genotoxicity of pesticides used for a long time, as well as about their metabolites, possible interaction between DNA andmultiple pesticides or pesticides and other chemicals in drinking water. Inview of the yet unclear and unpredictable processes occurring in the organism and the environment, it is crucial to protect human health by keeping concentrations of pesticides in drinking water as low as possiblePesticidi, ki se uporabljajo za zatiranje bolezni in škodljivcev rastlin, lahko vplivajo tudi na zdravje ljudi. Med potencialno škodljive učinke pesticidov na zdravje ljudi sodi tudi genotoksično delovanje - nastanek trajnih sprememb na deoksiribonukleinski kislini (DNK), t.i. mutacij. Posledica mutacije v telesni celici je lahko razvoj raka, mutacija v spolni celici pa se lahko prenese na potomce in sproži razvoj dedne bolezni ali povzroči splav. Genotoksični potencial snovi določamo s sklopom predpisanih testov. V okviru spremljanja stanja pitne vode v Sloveniji se določa prisotnost 55 pesticidov. Rezultati študij genotoksičnosti so znani za 23 od 55 pesticidov in nobeden od teh 23 nima genotoksičnega potenciala. V sklopu z zakonsko predpisanimi testi se določa tudi genotoksičnost nekaterih presnovkovpesticidov, ki nastajajo v organizmih in okolju. Ni pa znano, kako je z genotoksičnostjo pesticidov, ki so že dolgo v uporabi, kako se presnavljajo in kako delujejo na DNK v kombinaciji z drugimi pesticidi in kemikalijami v pitni vodi. Zaradi nepredvidljivih in za zdaj še nepoznanih dogajanj v organizmih in okolju je za zdravje ljudi najbolj pomembno, da je vsebnost pesticidov v pitni vodi čim nižjaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaInštitut za varovanje zdravja RS