137 KB31 KB199420252004Zaletel, Marjanštevilka:4letnik:43str. 363-372ISSN:0025-8121COBISSID:19161305URN:URN:NBN:SI:doc-S46FS301slMedicinski razglediMedicinski razglediBlood Flow VelocityCerebral ArteriesCerebrovascular CirculationCerebrovaskularni obtokEvocirani potenciali vidniEvoked Potentials, VisualKrvni pretok, hitrostMožganske arterijeneurologynevrologijaUltrasonografija dopplerska, transkranialnaUltrasonography, Doppler, Transcranialživčnožilna sklopitevAnaliza živčnožilne sklopitve z vidnimi evociranimi potenciali in doplersko sonografijo| The analysis of neurovascular coupling by visual evoked potentials and Doppler sonography|The term neurovascular coupling denotes the relationship between neuronal activity and regional cerebral blood flow. A method that would enable analysisof neurovascular coupling in humans is still to be discovered. The aimof our study was to establish whether it is possible to analyze neurovascular coupling noninvasively by simultaneously measuring visual evokedpotentials (VEP) and visually evoked cerebral blood flow responses (VEFR) by transcranial Doppler (TCD). The records were made from 30 healthy volunteers of both sexes aged 38.0 +- 9.6 years. The mean arterial velocity inthe left middle cerebral artery (vmMCA) and the mean arterial velocity in the right posterior cerebral artery (vmPCA) were monitored by using TCD. The VEPs were recorded from occipital leads. Neuronal activity was changed by changing visual contrast. The relationship between VEP and VEFR was tested using linear regression analysis. The VEFRs at 100% visual contrast were higher than those at 10% visual contrast (p < 0.01) and the VEFRs at 10% visual contrast higher than those at 1% visual contrast (p < 0.01). In addition, the VEPs at 100% visual contrast were higher than those at 10% visual contrast (p < 0.01) and the VEPs at 10% visual contrast higher than those at 1% visual contrast (p < 0.01). The relationship between the VEPs in the VEFR was moderate and significant (r = 0.66; p < 0.01). It was concluded that simultaneous measuring of VEPs and VEFRs enable us to analyze neurovascular coupling in healthy subjectsŽivčnožilna sklopitev je pojem, ki opredeljuje značilnost povezave med možganskim pretokom in živčno dejavnostjo. Zaenkrat ni uveljavljene metode, s katero bi analizirali živčnožilno sklopitev pri ljudeh. V študiji smo skušali ugotoviti, ali lahko analiziramo živčnožilno sklopitev tako, da sočasno merimovidne evocirane možganske odgovore krvnega pretoka (VEOP) s transkranialno doplersko sonografijo (TCD) in vidne evocirane potenciale (VEP). V raziskavo smo vključili 30 zdravih preiskovancev, starih 38,0 +- 9,61et obeh spolov. Srednjo arterijsko hitrost v levi srednji možganski arteriji (vmACM) in desni zadnji možganski arteriji (vmACP) smo merili s TCD. VEP smo izmerili iz zatilnih odvodov. Električno nevronsko dejavnost smo spreminjali s spreminjanjem vidnega kontrasta. Povezave smo testirali z linearno regresijo. Ugotovili smo, da so VEOP 100% vidnega kontrasta večji od VEOP 10% vidnega kontrasta (p < 0,01). VEOP 10% vidnega kontrasta so bili večji od VEOP 1% vidnega kontrasta (p < 0,01). VEP 100% vidnega kontrasta so bili v primerjavi z VEP 10% vidnega kontrasta večji (p < 0,01). VEP 10% vidnega kontrasta so bili večji od VEP 1% vidnega kontrasta (p < 0,01). VEP inVEOP so bili pri zdravih preiskovancih zmerno statistično pomembno povezani (r = 0,66; p < 0,01). Na temelju rezultatov smo zaključili, da lahko s sočasnim merjenjem VEOP in VEP analiziramo živčnožilno sklopitev pri zdravih preiskovancihTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi