29 KB60 KB21 KB199820252010Benedik, JanezKoželj, GordanaManohin, Aleksanderštevilka:1letnik:57str. 206-211ISSN:1318-0207COBISSID:26760665URN:URN:NBN:SI:doc-QBCSLNS7enSlovenian Chemical SocietySlovensko kemijsko društvoActa chimica slovenicaanalizna kemijamasna spektrometrijamidazolamplinska kromatografijaA study of midazolam plasma concentrations in patients undergoing conscius sedation|We studied midazolam plasma concentrations in patients undergoing middle ear surgery (MES) in local anesthesia and sedation. This study was based on the dinical measurement of the level of sedation and determination of the sedationdose of midazolam. For optimallevel of sedation for this type of surgery we suggest the midazolam plasma concentrations with median of 0.03 mg L -1 and range from 0.01-0.10 mg L -1. This can be contrasted to the other studies where considerably higher plasma concentrations of midazolam (0.2 mg L-1) were proposed (S. Michalk et al., Intens. Care Med. 1988, 15, 37-41). Despite low midazolam concentrations the level of sedation was adequateTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko kemijsko društvo