153 KB15 KB202220252022Smrtnik, Martinaštevilka:1str. 45-47COBISSID_HOST:122916611ISSN:2820-5014URN:URN:NBN:SI:doc-Q3H81E0HenslFakulteta za farmacijo, ŠSSFDPlaceboanti-inflammatory actionautoimmune diseasesAvtoimunske bolezniCitokinicurcumincytokineinflammationkurkumakurkuminprotivnetno delovanjeturmericvnetjeZdravilaProtivnetno delovanje kurkumina in njegova uporaba pri zdravljenju avtoimunskih bolezni|Curcumin is the main active substance of turmeric, most recognized for its anti-inflammatory action. It is a promising molecule for the treatment of autoimmune diseases. Studies in patients, who have included curcumin in their therapy, have shown a reduction in the severity of symptoms and easier maintenance of remissions. Additional studies would be required to determine effective standard doses, although curcumin is considered a fairly safe molecule. Currently, the biggest challenge is its poor bioavailability, as curcumin has very poor absorption and is metabolized rapidly. In order to overcome this issue and use curcumin as a therapeutic agent, different companies are developing formulations with new technologies, especially formulations with nanoparticlesKurkumin je glavna biološko aktivna snov v korenini kurkume in zanj je značilno protivnetno delovanje. Predstavlja obetavno molekulo za zdravljenje avtoimunskih bolezni. Raziskave pri pacientih, ki so v svojo terapijo vključili jemanje kurkumina, so pokazale zmanjšanje resnosti simptomov in lažje vzdrževanje remisij. Za ugotovitev učinkovitih standardnih odmerkov bi bilo treba izvesti dodatne študije, kljub temu pa kurkumin velja za precej varno molekulo. Trenutno je največji izziv slaba biološka uporabnost, saj se kurkumin v telesu slabo absorbira in hitro metabolizira. Proizvajalci vpeljujejo nove tehnologije, kot so formulacije z nanodelci, da bi rešili težave, ki se pojavljajo v terapevtski rabiTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of Slovenia