{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-PP7EQS6S/6b6ed7c4-2a37-44b6-b493-f39f99bb3c60/PDF","dcterms:extent":"377 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-PP7EQS6S/74323fb4-8764-4166-9578-9847408f9bf3/TEXT","dcterms:extent":"19 KB"}],"edm:TimeSpan":{"@rdf:about":"1998-2025","edm:begin":{"@xml:lang":"en","#text":"1998"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-PP7EQS6S","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-KC6O72BG"},{"@xml:lang":"sl","#text":"Acta chimica slovenica"}],"dcterms:issued":"2014","dc:creator":["Ambrus, Rita","Gergely, Matild","Sipos, Emese","Szabó-Révész, Piroska","Zvonar Pobirk, Alenka"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"letnik:61"},{"@xml:lang":"sl","#text":"str. 601-607"}],"dc:identifier":["ISSN:1318-0207","COBISSID:3735665","URN:URN:NBN:SI:doc-PP7EQS6S"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"diferenčna dinamična kalorimetrija"},{"@xml:lang":"en","#text":"intranasal powder formulation"},{"@xml:lang":"en","#text":"micronization"},{"@xml:lang":"en","#text":"pray-drying"},{"@xml:lang":"sl","#text":"predformulacijske študije"},{"@xml:lang":"sl","#text":"propranolol hidroklorid"},{"@xml:lang":"sl","#text":"propranolol hydrochloride"},{"@xml:lang":"sl","#text":"slv"},{"@xml:lang":"sl","#text":"stabilnost učinkovin"},{"@xml:lang":"en","#text":"structural analysis"}],"dcterms:temporal":{"@rdf:resource":"1998-2025"},"dc:title":{"@xml:lang":"sl","#text":"The role of co-spray-drying procedure on the preformulation of intranasal propranolol hydrochloride|"},"dc:description":[{"@xml:lang":"sl","#text":"The use of dry powder formulations presents an alternative through which to achieve better deposition and residence time in the nasal cavity, increased stability and possible absorption enhancement. The most important factors involved in the preformulation are particle size and physical stability. Propranolol hydrochloride a model drug was subjected to spray-drying technology to form an intranasal dry powder. Particle size reduction of the drug was carried out by integration (spray-drying) methods, using different excipients. The micrometric properties were characterized by size and morphology. The structure was determined through the use of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy investigations. It was concluded that the intranasal dry powder formulation of propranolol hydrochloride can be achieved with a suitable particle size without polymorph modification or chemical decomposition"},{"@xml:lang":"sl","#text":"Uporaba formulacij na osnovi suhih zmesi prahov predstavlja zanimivo alternativo tako za doseganje učinkovitejše dostave in daljšega časa zadrževanja učinkovin v nosni votlini kot tudi za izboljšanje njihove stabilnosti ter obsega absorpcije. V okviru predformulacijskih študij je potrebno posebno pozornost nameniti zlasti velikosti delcev prahov in fizikalni stabilnosti formulacije. Prašek za nos smo izdelali z metodo sušenja z razprševanjem, pri čemer smo kot modelno učinkovino uporabili propranolol hidroklorid. Ustrezno velikost delcev učinkovine smo zagotovili z izborom parametrov metode ter uporabo več pomožnih snovi. Izdelanim delcem mikrometrskih velikosti smo določili velikost in morfološke lastnosti. Njihovo strukturo smo nadalje ovrednotili z uporabo diferenčne dinamične kalorimetrije, rentgenske praškovne difrakcije in infrardeče spektroskopije s Fourierovo transformacijo. Potrdili smo, da z opisano metodo lahko pripravimo praške za nos z ustrezno velikostjo delcev, ne da bi pri tem prišlo do polimorfnih modifikacij ali kemijske razgradnje"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-PP7EQS6S","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-PP7EQS6S"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-PP7EQS6S/6b6ed7c4-2a37-44b6-b493-f39f99bb3c60/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-PP7EQS6S/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-PP7EQS6S"}}}}