23 KB110 KB20 KB192920262006Gubina, Marijaštevilka:3letnik:75str. 169-173ISSN:1318-0347COBISSID:21045721URN:URN:NBN:SI:doc-PKXOMJ8KslSlovensko zdravniško društvoZdravniški vestnikAge FactorsAntibodies, Bacterialbakterijske okužbeEpidemiologyHelicobacter InfectionsHelicobacter PyloriHelicobacter, infekcijeIgAIgGImmunologyprevalencaprotitelesaProtitelesa bakterijskaSex FactorsSpolni faktorjiStarostni faktorjiPrevalenca protiteles proti bakteriji Helicobacter pylori v Sloveniji v letu 2005| Prevalence of Helicobacter pylori antibodies in Slovenia in 2005|Background Helicobacter pylori infection is the most common human infection. Its prevalence is declin- ing in the Western world because of better sanitation and living conditions and because of medical treatment of symptomatic carriers of infection. The aim of the study was to find out the prevalence of infection in Slovenia in 2005. The antibody titer against bacteria Helicobacter pylori in tested sera was applied as detection tool. Patients and Serum samples from 1045 individuals from 0 to 90 years of age were collected. The labora- tory investigations by ELISA tests for IgG and IgAantibodies to Helicobacter pylori were performed at the Institute of Microbiology and Immunology Medical Faculty in Ljubljana. Patients were divided by decades into age groups, and by sex into male and female groups. Results The prevalence of seropositivity increases with age; there is no difference between men and women. The mean seropositivity rate is 25.1 % (95% CI 23-28%). The peak seropositi- vity rate is 54% (95% CI 40-69%) in the age group 60 to 69 years. There are 9.4% positive participants in the age group 0 to 19 and 29.6% seropositive participants in the age group between 20 and 49 years. Conclusions The Helicobacter pylori seropositivity rate has fallen dramatically in the last 15 years. The re is still more than one quarter of population younger than 45 years infected, which is very important in decidingabout the right therapeutic approach to that particular segment of ourpopulationIzhodišča. Okužba z bakterijo Helicobacter pylori je najpogostejša okužba pri ljudeh, vendar se prevalenca okužbe v razvitem delih sveta znižuje zaradi boljših higienskih in bivalnih razmer ter zdravljenja okužbe pri bolnikih z izraženimi kliničnimi težavami. V raziskavi smo želeli ugotoviti, kolikšna je bila pogostost okužbe v Sloveniji v letu 2005. Kot merilo smo izbrali navzočnost protiteles proti bakteriji Helicobacter pylori v serumu preiskovancev. Bolniki in metode. Pregledali smo serume 1045 preiskovancev, starih od 0 do 90 let. Z metodo ELISA smo protitelesa razredov IgG in IgA proti Helicobacter pylori določali na Inštitutu za mikrobiologijo in imunologijo Medicinske fakultete v Ljubljani. Rezultate smo prikazali za starostne skupine po dekadah, ločeno za moške in ženske. Rezultati. Prevalencaprotiteles proti Helicobacter pylori se veča s starostjo, enako pri moških in ženskah. Povprečno smo našli protitelesa pri 25,1% (95% IZ 23-28%) pregledanih oseb. Najpogosteje, v 54% (95% IZ 40-69%) smo jih našli pri preiskovancih v starostni skupini 60 do 69 let. V starosti od 0 do 19 let je imelo 9,4%, v starosti med 20 in 49 let pa je imelo 29,6% testiranih preiskovancev pozitivne vrednosti. Zaključki. Prevalence oseb s protitelesi proti bakteriji Helicobacter pylori se je v Sloveniji v zadnjih 15 letih močnozmanjšala, še vedno pa jih najdemo pri več kot četrtini prebivalcev Slovenije, mlajših od 45 let. To je pomemben podatek za izbiro pristopa k zdravljenju okužbe s to bakterijoTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo