{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-P062N4TZ/a807603b-3672-45cc-b979-87a66bb7777b/PDF","dcterms:extent":"359 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-P062N4TZ/d65781d9-3ef1-4da2-b9d6-eef8d3d360c7/TEXT","dcterms:extent":"57 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-P062N4TZ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"2013","dc:creator":["Jurič, Damijana Mojca","Žiberna, Lovro"],"dc:format":[{"@xml:lang":"sl","#text":"številka:2"},{"@xml:lang":"sl","#text":"letnik:52"},{"@xml:lang":"sl","#text":"str. 255-270"}],"dc:identifier":["ISSN:0025-8121","COBISSID:30647769","URN:URN:NBN:SI:doc-P062N4TZ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"sl","#text":"histamin"},{"@xml:lang":"en","#text":"histamine"},{"@xml:lang":"en","#text":"histamine receptor type 3"},{"@xml:lang":"sl","#text":"histaminski receptor tipa 3"},{"@xml:lang":"en","#text":"intracellular signaling"},{"@xml:lang":"sl","#text":"nevrofarmakologija"},{"@xml:lang":"sl","#text":"osrednje živčevje"},{"@rdf:resource":"http://www.wikidata.org/entity/Q61233"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Histaminski receptor tipa 3 - od gena do terapevtske tarče| Histamine receptor type 3 - from gene to drug target|"},"dc:description":{"@xml:lang":"sl","#text":"Histamine receptor type 3 was discovered in 1983 by Schwartz and coworkers and cloned in 1999. The expression ofhistamine receptor type 3 is largely confined to the central nervous system, where differential transcriptional and posttranscriptional processing lead to a high degree of molecular and functional heterogeneity. Histamine receptor type 3 has unique properties including constitutive activity in viva and the recruitment of plasticity-related signal transduction pathways, including Gai/0 - proteins, adenylyl cyclase, phospholipase Az, mitogen-activated protein kinase and Akt/glycogen synthase kinase 3 signalling. These make the histamine receptor type 3 the most prominent target for histaminergic drug development. Histamine receptor type 3 can function both as an auto receptor and as a heteroreceptor. As an autoreceptor on histaminergic neurons, histamine receptor type 3 activation inhibits celi firing, histamine synthesis and release. As a presynaptic heteroreceptors on other neurons, histamine receptors type 3 abundantly control the outf1ow of various neurotransmitters, including biogenic amines, acetylcholine, glutamate and y-amino butyric acid. The histamine receptor type 3 functioning is associated with cognition, behaviour, wakefulness and sleep regulation, locomotion, appetite regulation and pa in perception"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-P062N4TZ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-P062N4TZ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-P062N4TZ/a807603b-3672-45cc-b979-87a66bb7777b/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-P062N4TZ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-P062N4TZ"}}}}