{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-OYWGI3N8/c52ace3c-1303-4dd9-b572-bf757572e54c/PDF","dcterms:extent":"572 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-OYWGI3N8/b675d28e-9410-4f0b-9459-6699053c435c/TEXT","dcterms:extent":"0 KB"}],"edm:TimeSpan":{"@rdf:about":"1998-2025","edm:begin":{"@xml:lang":"en","#text":"1998"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-OYWGI3N8","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-KC6O72BG"},{"@xml:lang":"sl","#text":"Acta chimica slovenica"}],"dcterms:issued":"2023","dc:creator":["Gobec, Stanislav","Grošelj, Uroš","Gršič, Marija","Jukič, Marko","Knez, Damijan","Meden, Anže","Svete, Jurij"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:70"},{"@xml:lang":"sl","#text":"str. 545-559"}],"dc:identifier":["DOI:10.17344/acsi.2023.8460","ISSN:1580-3155","COBISSID:179806979","URN:URN:NBN:SI:doc-OYWGI3N8"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"dc:subject":[{"@xml:lang":"en","#text":"1,1’-Carbonyldiimidazole (CDI)"},{"@xml:lang":"sl","#text":"1,1’-karbonildiim-idazol (CDI)"},{"@xml:lang":"sl","#text":"amidacije"},{"@xml:lang":"en","#text":"amidations"},{"@xml:lang":"en","#text":"catalytic hydrogenation"},{"@xml:lang":"en","#text":"cholinesterase (ChE) inhibitors"},{"@xml:lang":"sl","#text":"derivati indola"},{"@xml:lang":"sl","#text":"derivati triptofana"},{"@xml:lang":"en","#text":"indole derivatives"},{"@xml:lang":"sl","#text":"katalitsko hidrogeniranje"},{"@xml:lang":"sl","#text":"prerazporeditve"},{"@xml:lang":"en","#text":"rearrangements"},{"@xml:lang":"en","#text":"tryptophan derivatives"},{"@xml:lang":"sl","#text":"zaviralci holinesteraze (ChE)"}],"dcterms:temporal":{"@rdf:resource":"1998-2025"},"dc:title":{"@xml:lang":"sl","#text":"Synthesis and cholinesterase inhibitory activity of selected indole-based compounds|"},"dc:description":[{"@xml:lang":"sl","#text":"Synthesis and anticholinesterase activity of 18 previously unpublished indole- and tryptophan-derived compounds are disclosed. These compounds containing an indole structural unit exhibit selective submicromolar inhibition of human butyrylcholinesterase (hBChE). The structures of the newly synthesized compounds were confirmed by ?$^1H$? and ?$^{13}NMR$?1H, IR spectroscopy, and high-resolution mass spectrometry"},{"@xml:lang":"sl","#text":"V članku je opisana sinteza in antiholinesterazna aktivnost 18 doslej neobjavljenih spojin, derivatov indola in triptofana. Spojine, ki vsebujejo indolni strukturni fragment, izkazujejo selektivno submikromolarno zaviranje človeške butirilholin esteraze (hBChE). Strukture na novo sintetiziranih spojin so bile potrjene z ?$^1H$? and ?$^{13} NMR$?1H, IR spektroskopijo in masno spektrometrijo visoke ločljivosti"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-OYWGI3N8","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-OYWGI3N8"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-OYWGI3N8/c52ace3c-1303-4dd9-b572-bf757572e54c/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko kemijsko društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-OYWGI3N8/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-OYWGI3N8"}}}}