{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-O3RXVQ8C/f3b71423-585b-47ee-bed7-a2c1743a6056/PDF","dcterms:extent":"254 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-O3RXVQ8C/42adc694-2560-4687-b587-5d85f26f3ec6/TEXT","dcterms:extent":"25 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-O3RXVQ8C","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2005","dc:creator":["Klokočovnik, Tomislav","Lipar, Luka","Rakovec, Peter","Zupan, Igor","Žižek, David"],"dc:format":[{"@xml:lang":"sl","#text":"letnik:74"},{"@xml:lang":"sl","#text":"str. I-79 - I-83"},{"@xml:lang":"sl","#text":"številka:suppl. 1"}],"dc:identifier":["ISSN:1318-0347","COBISSID_HOST:19268569","URN:URN:NBN:SI:doc-O3RXVQ8C"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"sl","#text":"Atrial Natriuretic Factor"},{"@xml:lang":"sl","#text":"Cardiac Pacing, Artificial"},{"@xml:lang":"sl","#text":"Electrodes, Implanted"},{"@xml:lang":"sl","#text":"Elektrode implantirane"},{"@xml:lang":"sl","#text":"Exercise"},{"@xml:lang":"sl","#text":"Heart Atrium"},{"@xml:lang":"sl","#text":"Methods"},{"@xml:lang":"sl","#text":"Preddvorni, natriuretični faktor"},{"@xml:lang":"sl","#text":"Prospective Studies"},{"@xml:lang":"sl","#text":"Prospektivne študije"},{"@xml:lang":"sl","#text":"Srce, predvor"},{"@xml:lang":"sl","#text":"Srčno vzpodbujanje, umetno"},{"@xml:lang":"sl","#text":"Telesna vadba"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Vpliv fizioloških dražljajev in nevrohumoralni odzivi pri preddvornoprekatni in sinhroni prekatni elektrostimulaciji srca| DDD and single lead VDD pacing: evolution of posture, exercise and plasma nutriuretic peptide levels|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. VDD pacing system is an alternative to DDD pacing system. Due to different fixation of electrodes in both systems, detected of atrial signal many vary greatly and can be influenced by posture and exercise. Inappropriateatrial sensing leads into loss of atrioventricular synchrony. Haemodynamic changes that occur have a distinctive influence on peripheral levels ANP and BNP. Methods. Our prospective study encompassed seventy-five patients with implanted VDD or DDD pacing system in year 2000. Using the programmer we directly measured sensing threshold in atrium supine, sitting upright and after standardized exercise. Among measured data we evaluated AV synchrony. Blood was collected from an antecubital vein and plasma proANP and NT-proBNP levels were measured. Results. Atrial sensing was significantly lower with VDD compared to DDD (p<0.001). The difference between supine and sitting upright among each pacing system was not significant (p=0.82). Atrial sensing was significantly lower after exercise compared to supine with VDD (p<0.05). VDD AV synchrony was lower (p<0.001). Difference of ANP levels was not significant (p=0.13). Levels of BNP were lower with VDD (p<0.05). Levels of ANP, BNP are negatively correlated to AV synchrony (o=-0.44, p<0.001 and o=-0.54, p<0.001, respectively). Levels of BNP and ANP are closely correlated (o=0.71, p<0,001). Conclusions. Posture did not have any significant effect onatrial sensing. However, in VDD pacing system atrial sensing was affected byexercise. Lower AV synchrony with VDD pacing system suggests lower haemodynamic support. Peripheral levels of natriuretic peptides were associated with AV synchrony. Therefore, haemodynamic affect can be predicted by measuring peripheral levels of either ANP or BNP"},{"@xml:lang":"sl","#text":"Izhodišča. Sinhrona prekatna stimulacija (VDD) je alternativa sekvenčnemu preddvornoprekatnemu (DDD) načinu spodbujanja. Zaradi različne vsaditve elektrode pri obeh sistemih lahko pride do razlik v zaznavanju preddvora gledena položaj telesa in telesne obremenitve. V primeru slabega zaznavanja v preddvoru se izgubi preddvornoprekatna usklajenost. Hemodinamske spremembe, kiob tem nastanejo, vplivajo na plazemsko raven hormonov ANP in BNP. Metode. Vprospektivno raziskavo smo vključili 75 preiskovancev, ki so jim leta 2000 vsadili srčni spodbujevalnik tipa VDD ali DDD. S programatorjem smo neposrednodoločili prag zaznavanja v preddvoru leže, sede in po standardizirani obremenitvi in izmerili vrednosti preddvorneprekatne usklajenosti. Preiskovancem smo nato odvzeli vensko kri in določili koncentracije proANP in NT-proBNP. Rezultati. Zaznavanje v preddvoru je bilo pri VDD manjše kot pri DDD (p<0,001). Vendar so razlike med ležečim in sedečimpoložajem znotraj posameznega tipa stimulacije nepomembne (p=0,82). PriVDD je prišlo do znižanja praga zaznavanja v preddvoru po obremenitvi gledena ležeč položaj (p<0,05). Pri VDD je bila preddvornoprekatna usklajenostmanjša (p<0,001). Razlika v koncentraciji ANP ni bila značilna (p=0,13). Koncentracija BNP je bila pri tipu VDD manjša (p<0,05). Koncentracija ANP in BNP ter preddvornoprekatna usklajenost sta negativno povezani (o=-0,44, p<0,001 oziroma o=-0,54, p<0,001). Koncentraciji BNP in ANPsta tesno povezani (o=0,71, p<0,001). (Izvleček skrajšan na 2000 znakov)"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-O3RXVQ8C","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-O3RXVQ8C"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-O3RXVQ8C/f3b71423-585b-47ee-bed7-a2c1743a6056/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-O3RXVQ8C/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-O3RXVQ8C"}}}}