46 KB142 KB43 KB192920262009Hočevar, AlojzijaJurčić, VesnaVizjak, Alenkaštevilka:6/7letnik:78str. 329-336ISSN:1318-0347COBISSID:25803737URN:URN:NBN:SI:doc-MLMGUWVCslSlovensko zdravniško društvoZdravniški vestnikAntibodies, Antineutrophil CytoplasmicBiopsijaBiopsyCryoglobulinemiaDiagnosishistopatologijaKožne bolezni žilkožne spremembeKrioglubulinemijaPathologyPoliarteritis nodozniPolyarteritis NodosaProtitelesa antinevtrofilna, citoplazemskaPurpura Schoenlein-HenochovaPurpura, Schoenlein-Henochsistemski vaskulitisSkin Diseases, VascularUrticariaUrtikarijaVasculitisVaskulitisKožni vaskulitisi in kožni pojavi pri sistemskih vaskulitisih| Cutaneous vasculitides and cutaneous manifestations of systemic vasculitides|Cutaneous vasculitis may be limited to the skin or may appear as part of systemic vasculitides. The type and intensity of changes depend on vessel sizeand the severity of involvement. The most common manifestation of small vesel vasculitis is palpable purpura, while vasculitis of medium-sized and large vessels usually express as livide noduses and ulcers. Cutaneous vasculitis may also manifest as bruises, erythema multiforme, papules, pustules, livedo and vesiculo-bullous lesions. The diagnostic procedure, in addition to clinical and laboratory investigations, frequently includes skin biopsy. Evaluation of tissue specimen includes standard histological examination of formalin fixed tissue and direct immunofluorescence of non-fixed fresh samples. The commonest histologic type of skin vasculitis is leukocytoclastic, which involves venules and capillaries and is a consequence of deposition of immune complexes with complement activation. Typical representatives are Henoch-Schönlein purpura, cryoglobulinemic vasculitis and vasculitis in systemic lupus erythematosus. Necrotizing arteriolitis and arteritis of small arteries are usually found in ANCA positive vasculitides. Medium-sized arteries can be involved in both ANCA positive vasculitides and polyarteritis nodosa. Conclusions This article presents the clinical picture, histopathologic characteristics, pathogenetic mechanisms and treatment of someclinicopathologic entities of vasculitides, such as Henoch-Schönlein purpura, urticarial vasculitis, cryoglobulinemic vasculitis, microscopic polyangiitis, Wegener's granulomatosis, Churg-Strauss syndrome and polyarteritis nodosaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo