249 KB52 KB199820252013Gašperlin, MirjanaGosenca, MirjamMravljak, JanezObreza, Alešštevilka:2letnik:60str. 310-322ISSN:1318-0207COBISSID:3475313URN:URN:NBN:SI:doc-JEMGSAXOenSlovenian Chemical SocietySlovensko kemijsko društvoActa chimica slovenicaamfifilne spojineamhiphilic moleculesamidoximesantioksidantiantioxidantantioxidant activitybenzoksimidimeri oksimovDPPH metodaglycolipid mimeticsoksimski derivati glikolipidnih mimetikovoximessintezastabilnost farmacevtskih učinkovinThe design, synthesis, and antioxidant activity of amphiphilic oximes and amidoximes|New amphiphilic benzamidoxime, benzoxime, and aliphatic oxime derivatives of glycolipid mimetics were synthesized. The total antioxidant capacity of these amphiphilic derivatives was evaluated using DPPH assay. The observed antioxidant activity was the highest for benzamidoxime derivatives and glycolipid mimetics with two oxime functionalities, followed by benzoxime derivatives, glycolipid mimetics with one oxime group, and dimers of oxime. Due to their amphiphilic structure, which was a guidance for compound design and synthesis, these novel amphiphilic compounds can be proposed as potential antioxidants for tackling oxidative processes in two-phase systems, either biological (cell membranes) or artificial (emulsions)Sintetizirali smo nove amfifilne spojine benzamidoksimskega in benzoksimskega tipa ter oksimske derivate glikolipidnih mimetikov z alkilno verigo. Celokupno antioksidativno kapaciteto amfifilnih derivatov smo ovrednotili z DPPH metodo. Benzamidoksimi in glikolipidni mimetiki z dvema oksimskima skupinama imajo najmočnejše antioksidativno delovanje, sledijo jim benzoksimski derivati, glikolipidni mimetiki z eno oksimsko skupino ter dimerioksimov. Zaradi amfifilne strukture, ki je bila vodilo pri načrtovanju in sintezi, bi nove sintetizirane amfifilne spojine lahko uporabili kot potencialne antioksidante za omejitev oksidativnih procesov v dvofaznih sistemih, tako bioloških (celične membrane) kot umetnih (emulzije)TEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko kemijsko društvo