{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-HQ4H3WJX/8f1d915a-31c5-40b4-8336-ae0e104d4a71/HTML","dcterms:extent":"26 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-HQ4H3WJX/8b45c30d-d025-477d-a9da-2556d27a80f7/PDF","dcterms:extent":"571 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-HQ4H3WJX/94f1b689-8e99-4670-9fc7-3e08e34478ae/TEXT","dcterms:extent":"23 KB"}],"edm:TimeSpan":{"@rdf:about":"1992-2025","edm:begin":{"@xml:lang":"en","#text":"1992"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-HQ4H3WJX","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-FNIFVE9S"},{"@xml:lang":"sl","#text":"Radiology and oncology (Ljubljana)"}],"dcterms:issued":"2011","dc:creator":["Adell, Gunnar","Gao, Jinfang","Lewander, Andreas","Sun, Xiao-Feng","Zhang, Hong"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:45"},{"@xml:lang":"sl","#text":"str. 279-284, III"}],"dc:identifier":["ISSN:1318-2099","COBISSID:29635289","URN:URN:NBN:SI:doc-HQ4H3WJX"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Association of Radiology and Oncology"},"dc:subject":[{"@xml:lang":"sl","#text":"Fosfoserin"},{"@xml:lang":"en","#text":"Gene Expression"},{"@xml:lang":"sl","#text":"Gensko izražanje"},{"@xml:lang":"en","#text":"Immunohistochemistry"},{"@xml:lang":"sl","#text":"Imunohistokemija"},{"@xml:lang":"sl","#text":"Limfatična metastaza"},{"@xml:lang":"en","#text":"Lymphatic Metastasis"},{"@xml:lang":"sl","#text":"NF-kapa B"},{"@xml:lang":"sl","#text":"Nf-Kappa B"},{"@xml:lang":"en","#text":"Pathology"},{"@xml:lang":"en","#text":"Phosphoserine"},{"@xml:lang":"en","#text":"Radiotherapy"},{"@xml:lang":"en","#text":"Rectal Neoplasms"},{"@xml:lang":"sl","#text":"Rektalne novotvorbe"},{"@xml:lang":"en","#text":"Tumor Markers, Biological"},{"@xml:lang":"sl","#text":"Tumorski označevalci biološki"}],"dcterms:temporal":{"@rdf:resource":"1992-2025"},"dc:title":{"@xml:lang":"sl","#text":"Expression of NF-kB p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy|"},"dc:description":{"@xml:lang":"sl","#text":"Background. In the present study, we investigated NF-eB p65 phosphorylated at Serine-536 (phosphor-Ser536-p65) in rectal cancer and its relationship to preoperative radiotherapy (RT), clinicopathological variables and biological factors.Patients and methods. Expression of phosphor-Ser536-p65 was examined by using immunohistochemistry in 141primary rectal cancers, 149 normal mucosa specimens and 48 metastases in the lymph nodes, from rectal cancer patients who participated in a Swedish clinical trial of preoperative RT. Results. The expression of phosphor-Ser536-p65 in the cytoplasm increased from normal mucosa to primary tumour (p<0.0001, for both the group that did and the group that did not received RT). The expression did not further increase from primary tumour to metastasis in either group (p>0.05). Expression of phosphor-Ser536-p65 was positively related to, or tended to be related to, theexpression of tumour endothelium marker 1 (TEM1, p=0.02), FXYD-3 (p=0.001),phosphatase of regenerating liver (PRL, p=0.02), p73 (p=0.048) and meningioma associated protein (MAC30, p=0.05) in the group that received RT but there were no such relationships in the group that did not received RT (p>0.05). The expression of phosphor-Ser536-p65 was not related to clinicopathological factors including survival (p>0.05). Conclusions. The increased expression of phosphor-Ser536-p65 may be involved in rectal cancer development. After RT, phosphor-Ser536-p65 seems to be positively related to the biological factors, which associated with more malignant features of tumours. However, phosphor-Ser536-p65 was not directly related to the responseof RT based on recurrence and survival"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-HQ4H3WJX","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-HQ4H3WJX"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-HQ4H3WJX/8b45c30d-d025-477d-a9da-2556d27a80f7/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo radiologije in onkologije"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-HQ4H3WJX/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-HQ4H3WJX"}}}}