{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-FV35BOSL/c477f7d8-be25-4351-8efe-2fa03605952d/PDF","dcterms:extent":"87 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-FV35BOSL/69f8df81-2f2b-44ac-80c2-ac2f96043816/TEXT","dcterms:extent":"43 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-FV35BOSL","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"1997","dc:creator":"Tul, Nataša","dc:format":[{"@xml:lang":"sl","#text":"letnik:36"},{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"str. 523-537"}],"dc:identifier":["ISSN:0025-8121","COBISSID:7988697","URN:URN:NBN:SI:doc-FV35BOSL"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"en","#text":"Alpha-fetoproteins"},{"@xml:lang":"en","#text":"Blood"},{"@xml:lang":"en","#text":"Counseling"},{"@xml:lang":"en","#text":"Diagnosis"},{"@xml:lang":"en","#text":"diagnostika"},{"@xml:lang":"en","#text":"Down syndrome"},{"@xml:lang":"sl","#text":"Downov sindrom"},{"@xml:lang":"en","#text":"Estriol"},{"@xml:lang":"en","#text":"False positive reactions"},{"@xml:lang":"en","#text":"Gonadotropins, chorionic"},{"@xml:lang":"en","#text":"Mass screening"},{"@xml:lang":"en","#text":"Maternal age 35 and over"},{"@xml:lang":"sl","#text":"porodništvo"},{"@xml:lang":"en","#text":"Pregnancy"},{"@xml:lang":"en","#text":"Prenatal diagnosis"},{"@xml:lang":"sl","#text":"prenatalna diagnostika"},{"@xml:lang":"sl","#text":"presejalni testi"},{"@xml:lang":"en","#text":"Trisomy"},{"@rdf:resource":"http://www.wikidata.org/entity/Q989120"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Presejalni hormonski testi za Downov sindrom| Hormonal screenig tests for Down syndrome|"},"dc:description":{"@xml:lang":"sl","#text":"Downov sindrom je najpogostejši posamezni vzrok za duševno zaostalost otrok. Prenatalno odkrivanje poteka v Sloveniji z amniocentezo in kariotipizacijo od leta 1981, in sicer s presejanjem na podlagi starosti matere. V letih 1987-94 smo prenatalno odkrili le 17% plodov z Downovim sindromom. Leta 1995 smo začeli s presejanjem s trojnim hormonskim testom v drugem trimesečju enoplodnih nosečnoti. v materini krvi določimo vrednosti alfafetoproteina, humanega horionskega gonadotropina in nekonjugiranega estriola ter izračunamo tveganje za rojstvo otroka z Downovim sindromom. Pričakujemo, da bomo odkrili približno 60% plodov z Downovim sindromom ob 5-7% lažno pozitivnih rezultatov. V članku predstavljamo praktične vidike testa in opisujemo hormone, ki jih določamo. Posebej opisujemo zaplete, ki se pojavljajo pri nosečnicah, ki so lažno vključene v skupino z visokim tveganjem za rojstvo otroka z Downovnim sindromom. Opisano je tudi presejanje z merjenjem nuhalne svetline in laboratorijske metode, ki bodo morda uporabne v prihodnosti"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-FV35BOSL","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-FV35BOSL"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-FV35BOSL/c477f7d8-be25-4351-8efe-2fa03605952d/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-FV35BOSL/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-FV35BOSL"}}}}