82 KB30 KB199420251998Malovrh, TadejPaternoster, Alenkaštevilka:1letnik:37str. 5-15ISSN:0025-8121COBISSID:7587545URN:URN:NBN:SI:doc-FTGKC8CTslMedicinski razglediMedicinski razglediBorrelia burgdorferidiagnostikaIggIgmImmunity, cellularImmunologyimunologijalimfocitiLyme boreliozaLyme diseaseLymphocyte transformationMerjenje celičnega imunskega odziva pri okužbi z Borrelio burgdorferi| Cellular immune response to Borrelia burgdorferi infection in man|The purpose of this study was to determine the diagnostic value of the lymphocyte blast transformation test in Lyme disease. Our laboratory results were compared with the diagnoses established by physicians. The course of the illness was followed in 213 individuals whose blood samples were tested for cell immunity against Borrelia burgdorferi. All patients showed clinical picture compatible with Borrelia burgdorferi infection. Sixty-five of the 213 patients (30.5%) developed cellular immunity, 4 (1.9o%) showed a non-specific cellular immune response, and 144 patients (67.6%) showed no cellular immune response to Borrelia burgdorferi antigens. The individuals were further divided into 5 groups by their clinical signs. In group 1, cellular immune response was observed in 45.8 per cent of patients, in group 2 in 57.1 per cent, in group 3 in 11.1 per cent, in group 4 22.1 per cent and in group 5 37.2 per cent of patientsNamen naše raziskave je bil določiti vrednost in diagnostični pomen testa blastnega preoblikovanja limfocitov pri lymski boreliozi. Primerjali smo laboratorijske rezultate z diagnozami, ki so jih postavili zdravniki. Spremljali smo potek bolezni pri 213 preiskovancih, katerih kri je bila poslana na testiranje celične imunosti za Borrelio burgdorferi. Pri vseh obravnavanih bolnikih je klinična slika ustrezala tisti pri lymski boreliozi. Ugotovili smo, da se je pri 65 bolnikih ali 30,5 % od 213 bolnikov razvil celični imunski odziv, pri 4 ali 1,9% imunski odziv ni bil značilen, pri 144 ali 67,6 % se celična imunost ni razvila. V nadaljevanju raziskave smo razdelili preiskovance po kliničnih znamenjih v 5 skupin. V prvi skupini smo pri 45,8 % bolnikov odkrili razvoj celičnega imunskega odziva, v drugi pri 57,1 %, v tretji pri 11,1 %, v četrti pri 22,1 % in v peti skupini pri 37,2 %TEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi