23 KB624 KB21 KB200020242012Aleksić, ZoranLazić, VojkanMilinković, IvaRaić, KarloRudolf, RebekaStamenković, DragoslavTodorović, Aleksandarštevilka:3letnik:46str. 251-256ISSN:1580-2949COBISSID:16057110URN:URN:NBN:SI:doc-CMDG6WL1enInštitut za kovinske materiale in tehnologijeMateriali in tehnologijeimplantatimplantatimicrostructuremikrostrukturamodifikacija površinesurface modificationtitan alloystitanove zlitineAspects of titanium-implant surface modification at the micro and nano levels| Oblike modifikacije titanovih implantatov na mikrometrskem in nanometrskem nivoju|The shape and chemical composition, as well as the macro- and microtopography, of an implant surface have been studied widely as the major factors that positively influence implant osseointegration. Titanium and titanium alloys have been used extensively over the past 20 years as biomedical materials in orthopedic and dental surgery because of their good mechanical properties, corrosion resistance, no cell toxicity, and very poor inflammatory response in peri-implant tissue, which confirms their high biocompatibility. Their favorable biological performance is attributed to a thin native oxide film that forms spontaneously on the titanium surface. It is well established that surface roughness plays an important role in implant fixation. Accordingly, some authors have indicated the existence of an optimal range of surface roughness. The titanium surface can be either chemically or physically modified, or both, in order to improve biomaterial-tissue integration. Different treatments are used to modify the titanium surface. Hydroxyapatite coatings, preceded or not by acid etching, are used to create a rough, potentially bioactive surface. Oxide blasting treatments, either with or without chemical etching, are used to develop roughsurfaces. Thick oxide films obtained by anodic or thermal oxidation have been used to accelerate the osseointegration process. The ideal microtopography of the surface is still unknown, however, because it is very difficult to associate surface properties with clinical results. As more accurate knowledge is required, several Ti surfaces have been analyzed and the endosseous implant surface modified on the micro level has been thoroughly studied. Additionally, the production of gold (Au) nanoparticles to be added to the micron-scale modified surface has been performed. In this respect, an appropriate overview of our results is givenOblika, kemična sestava in makro- ter mikrotopografija površine implantata so bile raziskovane kot najpomembnejši dejavnik, ki pozitivno vpliva na kostni prirast. Titan in njegove zlitine se uporabljajo več kot 20 let kot biomedicinski material v ortopedski in zobni kirurgiji zaradi dobrih mehanskih lastnosti, odpornosti proti koroziji, zaradi celične netoksičnosti in majhne vnetne reakcije s periplantatnim tkivom, kar vse potrjuje njihovo biokompatibilnost. Ugodno biološko vedenje se pripisuje tanki naravni oksidni plasti, ki spontano nastane na površini titana. Znano je, da ima hrapavost površine pomebno vlogo pri pritrditvi implantata. Temu ustrezno so nekateri avtorji omenili obstoj nekega optimalnega območja hrapavosti površine. Oblika površine titana se lahko spremeni kemijsko ali fizikalno ali na oba načina, kar poveča prirast biomateriala. Za spremembo oblike površine se uporablja več načinov. Hidroksiapatitna prekritja s predhodnim jedkanjem ali brez jedkanja s kislino se uporabljajo za tvorbo grobe, potencialno bioaktivne površine. Peskanje z oksidnim prahom s kemijskim jedkanjem ali brez njega se tudi uporablja za ustvarjanje grobe površine. Debele plasti oksida, nastale z anodno ali termično oksidacijo, se uporabljajo za pospešitev procesa kostnega prirastka. Idealna mikrotopografija površine je še vedno neznana, zato ker je težko uskladiti lastnosti površine s kliničnimi rezultati. Ker je potrebno boljše poznavanje, je bilo analiziranih več površin titana in modificirana površina implantata je bila na mikronivoju natačno preiskana. Dodatno so bili uporabljeni nanodelci zlata (Au) za dodatek na mikronivoju spremenjene površine. Ustrezen pregled doseženih rezultatov je predstavljen v tem prispevkuTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaInštitut za kovinske materiale in tehnologije