{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-BZCNKFOT/87e27244-df61-4ccb-a898-5febf7b2254b/PDF","dcterms:extent":"155 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-BZCNKFOT/8d1ac148-5a48-43c0-be9b-0cc90f7b6bb0/TEXT","dcterms:extent":"59 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-BZCNKFOT","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"2000","dc:creator":["Hudournik, Barbara","Oštir, Aljoša"],"dc:format":[{"@xml:lang":"sl","#text":"številka:3"},{"@xml:lang":"sl","#text":"letnik:39"},{"@xml:lang":"sl","#text":"str. 255-270"}],"dc:identifier":["ISSN:0025-8121","COBISSID:13017049","URN:URN:NBN:SI:doc-BZCNKFOT"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"en","#text":"Antithrombin iii"},{"@xml:lang":"en","#text":"Blood coagulation tests"},{"@xml:lang":"en","#text":"Deficiency"},{"@xml:lang":"en","#text":"Diagnosis"},{"@xml:lang":"en","#text":"diagnostika"},{"@xml:lang":"en","#text":"Family"},{"@xml:lang":"en","#text":"Genetics"},{"@xml:lang":"sl","#text":"genetika"},{"@xml:lang":"sl","#text":"krvne bolezni"},{"@xml:lang":"en","#text":"Protein c"},{"@xml:lang":"en","#text":"Protein s deficiency"},{"@xml:lang":"en","#text":"Risk factors"},{"@xml:lang":"en","#text":"Thromboembolism"},{"@xml:lang":"en","#text":"Thrombophlebitis"},{"@xml:lang":"sl","#text":"trombifilija"},{"@rdf:resource":"http://www.wikidata.org/entity/Q8436"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Odkrivanje trombofilije v družinah bolnikov z vensko trombozo| Investigating trombophilia in families of patients with venous thrombosis|"},"dc:description":[{"@xml:lang":"sl","#text":"Inherited trombophilia, state that predisposes individuals to venous thrombosis may be due to deficiency of antithrombin III, deficiency of proteinC or protein S, or resistance to activated protein C. The impact of hereditary trombophilia in familial venous thrombosis is not completely understood. It is known that hereditary trombophilia by itself does not necessarily lead to development of venous thrombosis and that additional risk factors have to be present. In the present study hereditary thrombophilia was investigated in the families of patients with venous thrombosis and hereditarythrombophilia. Differences in biological factors and differences in levels of hemostatic and hematological parameters between subjects with hereditary thrombophilia and venous thrombosis and assimptomatic carriers werestudied. Presence of the risk factor predisposing to venous thrombosis wasalso studied. 14 patients who had been diagnosed with venous thrombosis andinherited thrombophilia (8 females and 6 males, 25-50 years old, with a mean age of 41 years), and 34 close relatives of these patients (15 females and 19 males,11-80 years old, with a mean age of 44 years), were included. In all subjects we measured the activity of antithrombin III, proteins C and S, and resistance to activated protein C, as well as activated partial thromboplastin time, thrombin time, prothrombin time, fibrinogen, lupus anticoagulants, D-dimers, and complete blood cell count. Factors predisposing to venous thrombosis such as immobilisation of a limb, bed rest longer than three days, recent surgery, oral contraception, pregnancy and delivery were also assessed. (Abstract truncated at 2000 characters)"},{"@xml:lang":"sl","#text":"Med prirojeno trombofilijo, stanje, ki povečuje nagnjenje k venski trombozi, uvrščamo pomanjkanja antitrombina III, beljakovin C in S ter neodzivnosti na aktivirano beljakovino C. Številna vprašanja o vplivu prirojene trombofilije na družinsko pojavljanje venske tromboze še niso odgovorjena. Znano je, da prisotnost prirojene trombofilije sama po sebi ne vodi nujno do venske tromboze, pogosto so za njen nastanek potrebni dodatni sprožilni dejavniki. V raziskavi smo ugotavljali prisotnost prirojene trombofilije in venske trombozev družinah bolnikov, ki so že utrpeli vensko trombozo in imajo prirojeno trombofilijo. Iskali smo morebitne razlike v bioloških lastnostih invrednostih hemostatskih in hematoloških testov med osebami s prirojeno trombofilijo, ki so doživele vensko trombozo in asimptomatskimi nosilci trombofilije. Proučevali smo tudi pogostost izpostavljenosti sprožilnim dejavnikom, ki so povezani z nastankom venske tromboze. V raziskavo smo vključili 14 bolnikov s prebolelo vensko trombozo (8 žensk, 6 moških, starih od 25 do 50, poprečno 41 let), pri katerih smo v obdobju po preboleli akutni venski trombozi ugotovili prirojeno trombofilijo. K raziskavi smo pritegnili 34 bližnjih bolnikovih sorodnikov (15 žensk,19 moških, starih od 11 do 80 let,poprečno 44 let). Pri vseh preiskovancih smo merili aktivnost antitrombinaIII, beljakovin C in S ter neodzivnost na aktivirano beljakovino C. Merili smo tudi aktivirani parcialni tromboplastinski čas, trombinski čas, fibrinogen, protrombinski čas, lupusne antikoagulante, D-dimere ter osnovne hematološke parametre. Ovrednotili smo pogostost bolnikove izpostavljenosti dejavnikom tveganja za nastanek venske tromboze, med katere smo uvrstili imobilizacijo uda, mirovanje dlje kot tri dni, nedavno operacijo, oralno kontracepcijo, nosečnost in porod. (Izvleček skrajšan pri 2000 znakih)"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-BZCNKFOT","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-BZCNKFOT"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-BZCNKFOT/87e27244-df61-4ccb-a898-5febf7b2254b/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-BZCNKFOT/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-BZCNKFOT"}}}}