39 KB76 KB38 KB192920262001Pfeifer, Marijaštevilka:5letnik:70str. 295-299COBISSID:13152217ISSN:1318-0347URN:URN:NBN:SI:doc-BOXIY6BAslSlovensko zdravniško društvoZdravniški vestnikAdultDeficiencyDrug therapyfiziologijaHypopituitarismkvaliteta življenjaMetabolismodraslirastrastni hormoniSomatotropinSomatotropins, recombinanttherapyzdravljenjeSindrom pomanjkanja rastnega hormona pri odraslem - učinki nadomestnega zdravljenja| Syndrome of growth hormone deficiency in adults - effects of growth hormone replacement therapy|Background. After the cessation of longitudinal growth, growth hormone (GH) continues to subserve an important role in the regulation of body metabolism (stimulation of lipolysis and lipid oxidation, protein synthesis, insulin antagonism, and sodium and water retention) to optimise body composition and function. Most patients with hypopituitarism exhibit the syndrome of GH deficiency with a number of abnormal features which can be reversed with recombinant GH replacement therapy. Conclusions. GH-deficient patients have decreased lean body mass and bone mineral content, increased fat mass, reducedmuscle strength and exercise performance, dyslipidemia and increased prevalence of other risk factors for atherosclerosis. They exhibit increased cardiovascular morbidity and mortality and impaired quality of life. It has been shown that GH replacement normalises body composition and exercise capacity, reverses early atherosclerotic changes in major arteries, improves cognitive functions and quality of life. As the treatment with recombinant GH is life-long and expensive it should be offered to patients who exhibit most symptoms and have heen proven to have severe GH-deficiencvIzhodišča. Po končani telesni rasti se rastni hormon (RH) iz hipofize še naprej izloča in z urejanjem presnove (spodbujanjem lipolize, sinteze beljakovin, štedenjem glukoze in zadrževanjem natrija in vode) vzdržuje optimalno telesno sestavo in zmogljivost. Večina bolnikov s hipopituitarizmom ne izloča dovolj RH, zato pri njih nastane sindrom pomanjkanja RH. Odkar je navoljo rekombinantni humani RH, jih lahko uspešno zdravimo z nadomeščanjem RH. Zaključki. Zaradi pomanjkanja RH imajo bolniki zmanjšano mišično in kostnomaso, povečano količino maščobnega tkiva, zmanjšano mišično moč in telesno zmogljivost, dislipidemijo in povečano prevalenco drugih dejavnikov ogrožanja za aterosklerozo. Pogosteje zbolevajo in umirajo za srčnožilnimi boleznimi in imajo slabšo kakovost življenja. Nadomeščanje RH pri bolnikih ublaži ali odpravi simptome in znake pomanjkanja RH: normalizira telesno sestavo in zmogljivost, izboljša kognitivne sposobnosti in življenjsko kakovost ter zmanjša dejavnike ogrožanja in zgodnje znake ateroskleroze. Ker je rekombinantni RH drag, uvajamo nadomestno zdravljenje z RH pri bolnikih, kiimajo najbolj izražene bolezenske znake in jim s testi dokažemo hudo pomanjkanje RHTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo