173 KB74 KB199420252001Kaplan, PetraKorošec, Saraštevilka:1letnik:40str. 3-22ISSN:0025-8121COBISSID:13903577URN:URN:NBN:SI:doc-BL0TB1PWslMedicinski razglediMedicinski razglediChromosome abnormalitiesDiagnosisEmbryo transferEpidemiologyfertilizationFertilization in vitroInfant, newbornkromosomske nepravilnostioploditevOvulation inductionporodništvoRisk factorszunajtelesna oploditevPogostost kromosomskih nepravilnosti pri otrocih, rojenih z biomedicinsko pomočjo| Rates of chromosomal anomalies in children conceived after assisted reproductive techniques|Background. Despite doubts about safety of in vitro fertilisation-embryo transfer (IVF-ET), intracytoplasmic sperm injection (ICSI) and use of frozen embryos, statistical analyses up to date have shown that risk of congenital malfomations is not essentially different from the risk in case of natural conception. The only fact that was shown is that in neonates born after ICSI procedure, abnormalities of sex chromosomes were present more often. Risk factors of sterile couples are: their age, sterility and frequent multiple pregnancies. An assessment of prevalence and distribution of chromosomal and structural malformations in our country would be useful in treating the sterile couples in the future.Aim and hypothesis. The aim of the survey is to determine whether rates of congenital malformations in neonates born after assisted reproductive techniques are higher than in neonates born after a spontaneous conception.Patients and methods. 242,164 neonates born to 241,607 mothers from April 1987 to December 1997 in Slovenia, were included in retrospective survey. The survey was divided into 3 cohort and 1 case-controlled studies. In first two studies prevalence of chromosomal, structural and lethal abnormalities were observed. In first study we compared 1404 neonates born after IVF-ET procedure with neonates born after spontaneousconception. In second controlled study we compared 1270 neonates born after IVF-ET procedure with 1270 neonates born after spontaneous conception, whose mothers were matched according to their age, multiplicity, parity and year of birth. In third study we observing the shares of congenitalabnormality rates according to a form of fertilisation. We compared 73 neonates with congenital abnormalities, born after IVF-ET procedure with 9685 neonates with congenital abnormalities, born after spontaneous conception. (Abstract truncated at 2000 characters)Izhodišče. Kljub dvomom o varnosti postopka oploditve v epruveti s prenosom zarodka (IVF-ET), postopka oploditve z vbrizganjem spermija v citoplazmo (ICSI) in uporabi zamrznjenih zarodkov raziskave kažejo, da tveganje za prirojene nepravilnosti ni bistveno povečano. Izkazalo se je le, da so pri novorojenčkih, rojenih po oploditvi s postopkom ICST, pogostejše nepravilnostispolnih kromosomov. Dejavniki tveganja neplodnih parov so njihovavišja starost, neplodnpst in pogostejše mnogoplodne nosečnosti. Ocena pojavnosti kromosomskih, pa tudi strukturnih prirojenih nepravilnosti pri nas bi bila uporabna pri obravnavi neplodnih parov v prihodnosti. Namen in hipoteze raziskave. V naši raziskavi želimo ugotoviti, ali so prirojene nepravilnosti pri novorojenčkih, rojenih po postopkih oploditve z biomedicinsko pomočjo, pogostejše kot pri žovorojenčkih, rojenih po spontani zanositvi. Preiskovanke in metode dela. V retrospektivno raziskavo smo vključili 242.164 novorojenčkov, ki so se rodili 241.607 materam od aprila 1987 do decembra 1997 v Sloveniji, ter jo razdelili na 3 kohortne in 1 kontrolirano študijo. V prvih dveh študijah smo primerjali pojavnost kromosomskih, strukturnih in letalnih prirojenih nepravilnosti. Pri prvi študiji smo primerjali 1404 novorojenčkov, rojenih po oploditvi s postopkom IVF-ET, z novorojenčki, rojenimi po spontani zanositvi. Pri drugi, kontrolirani študiji, smo primerjali 1270 novorojenčkov rojenih po oploditvi mater s postopkom IVF-ET, s 1270 novorojenčki, rojenimi materam po spontani zanositvi ob tem, da smo matere po starosti, številu plodov, pariteti in letu poroda izenačili. Pri tretji študiji smo ugotavljali pojavnost kromosomskih, strukturnih in letalnih prirojenih nepravilnosti glede na način oploditve. 73 novorojenčkov s prirojenimi nepravilnostmi, rojenih po oploditvi s postopkom IVF-ET, smo primerjali s 9685 novorojenčki s prirojenimi nepravilnostmi, rojenimi po spontani zanositvi. (Izvleček skrajšan pri 2000 znakih)TEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi