{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-BJR1KEPS/fe3049be-0ddf-40ae-88f6-43189bef3772/HTML","dcterms:extent":"49 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-BJR1KEPS/92d6484f-d6d4-42a8-99ea-41d269597715/PDF","dcterms:extent":"118 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-BJR1KEPS/90c5d59e-842c-48ae-9155-0c0ac11fbb3f/TEXT","dcterms:extent":"41 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-BJR1KEPS","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2007","dc:creator":["Čižek-Sajko, Mojca","Kovač, Vilma","Vlaisavljević, Veljko"],"dc:format":[{"@xml:lang":"sl","#text":"številka:1"},{"@xml:lang":"sl","#text":"letnik:76"},{"@xml:lang":"sl","#text":"8 strani"},{"@xml:lang":"sl","#text":"str. 19-26"}],"dc:identifier":["ISSN:1318-0347","COBISSID:2554431","URN:URN:NBN:SI:doc-BJR1KEPS"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"Chorionic Gonadotropin"},{"@xml:lang":"en","#text":"Fertilization in Vitro"},{"@xml:lang":"sl","#text":"Folikel stimulirajoči hormon"},{"@xml:lang":"en","#text":"Follicle Stimulating Hormone"},{"@xml:lang":"sl","#text":"Horionski gonadotropin"},{"@xml:lang":"en","#text":"human pregnancy"},{"@xml:lang":"en","#text":"in vitro fertilization"},{"@xml:lang":"sl","#text":"jajčne celice"},{"@xml:lang":"sl","#text":"neplodnost"},{"@xml:lang":"sl","#text":"Nosečnost"},{"@xml:lang":"en","#text":"Oociti"},{"@xml:lang":"en","#text":"Oocytes"},{"@xml:lang":"sl","#text":"Oploditev in vitro"},{"@xml:lang":"sl","#text":"Policistični jajčnik, sindrom"},{"@xml:lang":"en","#text":"Polycystic Ovary Syndrome"},{"@xml:lang":"en","#text":"Pregnancy"},{"@xml:lang":"en","#text":"therapy"},{"@xml:lang":"sl","#text":"zdravljenje"},{"@xml:lang":"sl","#text":"zunajtelesna oploditev"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Zorenje človeških jajčnih celic v pogojih in vitro| Maturation of human oocytes in vitro|"},"dc:description":[{"@xml:lang":"sl","#text":"Background. Immature oocyte retrieval followed by in vitro maturation is a promising infertility treatment option. In patients with morphologically normal ovaries and regular menstrual cycles and in patients with polycystic ovary syndrome (PCOS) we attempted to assess the success of oocyte in vitro maturation in in vitro fertilization (IVF) procedures. Methods. Retrospectively we analyzed 87 IVF procedures with in vitro maturation of oocytes carried out in 73 infertile couples treated at the Maribor Teaching Hospital. We compared the success following three different hormone priming protocols: regular cycling patients with normal ovaries and without hormone priming (Group A, n = 27); patients with PCOS and hormone priming with follitropin (follicle stimulating hormone, FSH) (Group B, n = 22); patients with PCOS and hormone priming with human chorionic gonadotrophin (hCG) (Group C, n = 38). Success of the procedure was evaluated on the basis of the ability of oocytes to mature, fertilize and develop into embryos, and on the basis of the quality of embryos and their ability to implant in the uterus. Results. In regular cycling patients with normal ovaries (n = 27) we obtained a significantly lower number of immature oocytes (3.2 + 2.5) compared with patients with PCOS and FSH priming (11.7 + 7.2) or those with PCOS and hCG priming (10.4 + 7.2). The oocyte maturation rate, the fertilization rate and the embryo cleavage rate were as follows: in Group A 57.7 %, 63.2 % and 91.7 %, in Group B 57.6 %, 66.2 % and 90.0 %, and in Group C 58.0 %, 66.2 % and 91.0 % (the differences between groups were not statistically significant). Six pregnancies were recorded only in patients with PCOS. The pregnancy rate per embryo transfer was 1/20 (5.0 %) in patients with FSH priming, and 5/33 (15.2 %) in patients with hCG priming. Conclusions. Oocyte in vitro maturation is successful in patients with normal ovaries and regular menstrual cycle as well as in those with polycystic ovary syndrome. Clinically the method of in vitro maturation of oocytes in IVF procedures is particularly justified in patients with PCOS. The hCG priming protocol proved the most successful hormone priming protocol for patients prior to puncture of immature follicles"},{"@xml:lang":"sl","#text":"Izhodišča. Pridobivanje nezrelih jajčnih celic in nato zorenje v pogojih in vitro je obetajoča metoda zdravljenja neplodnosti. Pri preiskovankah z morfološko normalnimi jajčniki in rednim menstruacijskim ciklusom ter pri preiskovankah s sindromom policističnih jajčnikov (PCOS) smo v postopkih zunajtelesne oploditve ugotavljali uspešnost zorenja jajčnih celic v pogojih in vitro. Metode. Pri 73 neplodnih parih smo retrospektivno analizirali 87 postopkov zunajtelesne oploditve z zorenjem jajčnih celic v pogojih in vitro. Primerjali smo uspešnost treh različnih protokolov hormonske priprave preiskovank: preiskovanke z normalnim menstruacijskim ciklusom in brez hormonskega spodbujanja (skupina A, n = 27); preiskovanke s PCOS in hormonsko pripravo s folitropinom (folikle spodbujajočim hormonom, FSH) (skupina B, n = 22); preiskovanke s PCOS in hormonsko pripravo s humanim horionskim gonadotropinom (hCG) (skupina C, n = 38). Uspešnost postopka smo ovrednotili s sposobnostjo jajčnih celic za zorenje, za oploditev in za razvoj v zarodke ter s kakovostjo zarodkov in njihovo sposobnostjo za ugnezditev v maternico. Rezultati. Pri preiskovankah z normalnim menstruacijskim ciklusom (n= 27) smo dobili bistveno manj nezrelih jajčnih celic (3,2 + 2,5) kot pri preiskovankah s PCOS in spodbujanih s FSH (11,7 + 7,2) oziroma preiskovankah s PCOS in spodbujanih s hCG (10,4 + 7,2). Stopnja dozorevanja jajčnih celic, stopnja oploditve in stopnja delitve zigot v zarodke je bila pri skupini A 57,7 %, 63,2 % in 91,7 %, pri skupini B 57,6 %, 66,2 % in 90,0 %, ter pri skupini C 58,0 %, 66,2 % in 91,0 % (razlike med skupinami so bile statistično neznačilne). Šest zanositev smo zabeležili le pri preiskovankah s PCOS. Delež zanositve na prenos zarodkov je bil 1/20 (5,0 %) pri preiskovankah, spodbujanih s FSH, in 5/33 (15,2 %) pri preiskovankah, spodbujanih s hCG. Zaključki. Zorenje jajčnih celic v pogojih in vitro je uspešno tako pri preiskovankah z morfološko normalnimi jajčniki in rednim menstruacijskim ciklusom kot pri preiskovankah s sindromom policističnih jajčnikov. Metoda zorenja jajčnih celic v pogojih in vitro v postopku zunajtelesne oploditve je klinično uporabna predvsem za preiskovanke s PCOS. Kot najuspešnejši protokol hormonske priprave preiskovank na punkcijo nezrelih foliklov se je izkazal protokol spodbujanja s hCG"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-BJR1KEPS","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-BJR1KEPS"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-BJR1KEPS/92d6484f-d6d4-42a8-99ea-41d269597715/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-BJR1KEPS/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-BJR1KEPS"}}}}