653 KB18 KB202220252025Bizjak, Kajaštevilka:4str. 15-18COBISSID_HOST:248494595ISSN:2820-5014URN:URN:NBN:SI:doc-6WM0T7MZslFakulteta za farmacijo, ŠSSFDPlacebogeneticsgenetikainflammationpathophysiologypatofiziologijaRosacearozaceasistemska terapijasystemic therapyvnetjeRozacea kot izziv celostne obravnave| splošno o dermatoveneroloških boleznih|Rosacea is a chronic infl ammatory skin disease that clinically presents with erythema, papules, pustules, teleangiectasias, and, in more severe cases, phymatous changes and ocular involvement. Its development is infl uenced by a complex interplay between the immune and nervous systems, as well as environmental factors such as UV radiation. Treatment is individually tailored based on the clinical phenotype and includes topical and systemic agents, such as metronidazole, ivermectin, and doxycycline. Newer options, including foambased minocycline, have also emerged. Promising therapeutic approaches are currently under development. A holistic approach is essential, incorporating trigger avoidance, lifestyle modifi cations, and psychological support when needed. Early recognition and timely treatment signifi cantly infl uence disease progression and improve patients’ quality of lifeRozacea je kronična vnetna bolezen kože, ki se klinično kaže z rdečico, papulami, pustulami, teleangiektazijami in v težjih primerih s fi matoznimi spremembami ter z očesnimi težavami. Na njen razvoj vpliva zapletena interakcija med imunskim in živčnim sistemom ter okoljskimi dejavniki, kot je UV-sevanje. Zdravljenje se individualno prilagodi glede na klinično sliko. Vključuje učinkovine za lokalno in sistemsko zdravljenje, kot so metronidazol, ivermektin in doksiciklin. Med novejše možnosti terapije uvrščamo zdravljenje z minociklinom v obliki pene. Ključnega pomena je celosten pristop, ki vključuje izogibanje sprožilcem, prilagoditev življenjskega sloga in po potrebi psihološko podporo. Zgodnje prepoznavanje bolezni in pravočasno zdravljenje pomembno vplivata na potek bolezni in izboljšujeta kakovost življenja bolnikovTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of Slovenia