{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-4TGD56ZJ/1407f106-bfab-4c99-8b88-a016f4d5dc2f/PDF","dcterms:extent":"123 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-4TGD56ZJ/52b17fda-1162-4676-861a-d57ff86ff631/TEXT","dcterms:extent":"28 KB"}],"edm:TimeSpan":{"@rdf:about":"1994-2025","edm:begin":{"@xml:lang":"en","#text":"1994"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-4TGD56ZJ","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-46R7GGHL"},{"@xml:lang":"sl","#text":"Medicinski razgledi"}],"dcterms:issued":"2004","dc:creator":["Kocjan, Boštjan","Poljak, Mario","Seme, Katja"],"dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:43"},{"@xml:lang":"sl","#text":"str. 411-418"}],"dc:identifier":["ISSN:0025-8121","COBISSID:19162073","URN:URN:NBN:SI:doc-4TGD56ZJ"],"dc:language":"sl","dc:publisher":{"@xml:lang":"sl","#text":"Medicinski razgledi"},"dc:subject":[{"@xml:lang":"en","#text":"bacteria"},{"@xml:lang":"en","#text":"Bacterial Typing Techniques"},{"@xml:lang":"sl","#text":"bakterije"},{"@xml:lang":"sl","#text":"Bakterijska tipizacija, tehnike"},{"@xml:lang":"en","#text":"diagnostika"},{"@xml:lang":"en","#text":"Genes, Bacterial"},{"@xml:lang":"en","#text":"Genetics"},{"@xml:lang":"sl","#text":"genetika"},{"@xml:lang":"sl","#text":"Geni bakterijski"},{"@xml:lang":"en","#text":"Methicillin Resistance"},{"@xml:lang":"sl","#text":"Meticilinska rezistenca"},{"@xml:lang":"sl","#text":"odpornost"},{"@xml:lang":"sl","#text":"Polimerazna, verižna reakcija"},{"@xml:lang":"en","#text":"Polymerase Chain Reaction"},{"@xml:lang":"en","#text":"Staphylococcus Aureus"},{"@rdf:resource":"http://www.wikidata.org/entity/Q7162"}],"dcterms:temporal":{"@rdf:resource":"1994-2025"},"dc:title":{"@xml:lang":"sl","#text":"Genetska osnova odpornosti Staphylococcus aureus proti meticilinu| Genetic background of the Staphylococcus aureus methicillin resistance|"},"dc:description":[{"@xml:lang":"sl","#text":"Methicillin-resistant Staphylococcus aureus (MRSA) was firstreported over 30 years ago. Within a decade, MRSA was established as an important nosocomial pathogen in both the adult and pediatric populations. MRSA has also emerged asa pathogen in adults and children without traditional risk factors for MRSA infection. Recent studies have demonstrated that these strains have novel resistance and virulence genes. This review focuses on the epidemiology of MRSA infections and the genetic background of methicillin resistance. The genetic background of methicillin resistance and the transfer of the resistance genes between staphylococci are discussed. A theory of MRSA evolution and the development of major globally spread MRSA clones are presented. In addition, widely used methods for the diagnostic and typing of MRSA isolates are also summarized"},{"@xml:lang":"sl","#text":"Proti meticilinu odporen Staphylococcus aureus (MRSA) je bil prvič izoliran pred več kot 30 leti in kmalu postal eden najpomembnejših povzročiteljev bolnišničnih okužb tako pri odrasli kot tudi pri otroški populaciji. V zadnjemčasu se v izvenbolnišničnem okolju vse pogosteje soočamo s pojavljanjemsevov MRSA, ki se po dejavnikih odpornosti in virulence ter dejavnikov tveganja za okužbo z MRSA razlikujejo od znanih bolnišničnih sevov.Pričujoči prispevek podaja pregled obstoječe literature o epidemiologijiokužb z MRSA in vzrokih odpornosti proti meticilinu. Podrobno jeopisana sestava genetskih elementov, ki so osnova odpornosti proti meticilinu in ostalim betalaktamom. V nadaljevanju je predstavljena teorija o prenosu odpornosti proti meticilinu med stafilokoki ter opisani ključni dogodki v evoluciji, ki so verjetno privedli do nastanka različnih klonov MRSA. V zadnjem delu pregleda so predstavljene molekularne metode, ki se najpogosteje uporabljajo v diagnostiki okužb z MRSA in pri tipizaciji kliničnih izolatov MRSA"}],"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-4TGD56ZJ","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-4TGD56ZJ"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-4TGD56ZJ/1407f106-bfab-4c99-8b88-a016f4d5dc2f/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Društvo Medicinski razgledi"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-4TGD56ZJ/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-4TGD56ZJ"}}}}