408 KB85 KB199420252013Sajko, SaraSollner Dolenc, Marijaštevilka:1letnik:52str. 29-48ISSN:0025-8121COBISSID:3393393URN:URN:NBN:SI:doc-4FRLFEQXslMedicinski razglediMedicinski razgledihipertenzijaimunski sistemkostipolimorfizmipomanjkanjerak (medicina)vitamin DVzroki in posledice pomanjkanja vitamina D| Causes and consequences of vitamin D deficiency|Vitamin D is a fat-soluble vitamin involved in the regulation of calcium homeostasis, glucose metabolic pathway and renin expression. It is also capable of immunomodulation and anticancerogenic activity. Vitamin D status of inhabitants at some geographical latitudes is insufficient because of limited UVB radiation. The question that arises from this is what the appropriate vitamin D concentration for maintaining health is and how much dosage is needed to prevent its deficiency. When measuring 25-hydroxyvitamin D, insufficiency starts at levels lower than 75 nmol/l. The purpose of this review is to inform how simple it is to provide the appropriate body amount of vitamin D as well as to elucidate vitamin D involvement in mechanisms of some other diseases besides its well-known roles in bone remodelling disorders(e.g. rickets, osteoporosis)Vitamin D je v maščobi topen vitamin, vpleten v regulacijo homeostaze kalcija, metabolične poti glukoze in ekspresije renina, sposoben pa je tudi imunomodulacije ter ima protirakavo delovanje. Na določenih geografskih širinah je preskrbljenost prebivalstva z vitaminom D zaradi omejene količine ultravijoličnih žarkov B neustrezna, zato se poraja vprašanje, katere koncentracije vitamina D lahko zadostijo osnovnim potrebam človeškega telesa, ter predvsem, kolikšni so primerni odmerki, da preprečimo njegovo pomanjkanje.Le-to naj bi nastopilo, ko koncentracija merjenega serumskega 25-hidroksivitamina Dpade pod 75 nmol/l. Namen članka je opozoriti, kako preprosta je pot, da si zagotovimo ustrezno koncentracijo vitamina D v telesu,ter poleg znanih motenj v izgradnji kostnine (rahitis, osteoporoza), ki nastanejo zaradi njegovega pomanjkanja, osvetliti vlogo vitamina D v mehanizmih nastanka nekaterih drugih bolezniTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaDruštvo Medicinski razgledi