22 KB561 KB21 KB192920262010Rožman, PrimožŠimc, Mojcaštevilka:126 straniletnik:79str. 864-869ISSN:1318-0347COBISSID:27830489URN:URN:NBN:SI:doc-4ED6WXE8enSlovensko zdravniško društvoZdravniški vestnikbabyBiliarna atrezijaBiliary AtresiaBlood Component TransfusionBlood Grouping And CrossmatchingDojenčekdojenčkiEritrocitieritrocitna protitelesaErythrocytesIggInfantIsoantibodiesIzoprotitelesaKrvna sestavina, transfuzijakrvne skupineKrvne skupine in navzkrižno določanjeprotitelesaSurgerytestiranjetransfuzija krviNaturally occurring anti-E red-cell antibodies in a 3-month old infant| Naravna anti-E eritrocitna protitelesa prisotna pri trimesečnem otroku|Background: Before the transfusion of the red blood cells containing blood components is applied, pre-transfusion testing such as ABO, RhD and Kell bloodgrouping with a negative crossmatch is obligatory. This can be reduced toblood grouping only in infants less than 4 months of age, provided that the initial antibody screening test is negative. Only a few cases of antibody formation in such young infants have been described, the majority of them haveresulted from exposure to allogeneic transfusions. Case report: During thepre-transfusion testing, naturally occurring anti-E red blood cell antibodies were detected in a 3-month old male infant, who underwent surgery for atresia of the extra hepatic bile ducts followed by a bacterial infection.All immunohaematological tests were performed using the commercial gel column agglutination method, screening cells, RBC panel and enzyme-modified cells according to the manufacturerćs instructions. The passive transfer of anti-E antibodies with blood components and the transfer of the antibodies from the mother during pregnancy and also through lactation were excluded. Immunisation due to exposure to E antigen was ruled out by confirming the E-negativity of all the red blood cell units the infant had received and also by confirming the E-negativity of the mother. Conclusion: Although the naturally occurring anti-E red-cell antibodies are usually found in adults, we report here a case of a 3-month old infant, who had developed naturally occurring anti-E red cell antibodiesTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo