31 KB130 KB26 KB200220262003Frelih, TatjanaJanet, EvgenPeternelj, BrigitaPetraš, TeodoraSočan, Majaštevilka:4letnik:42str. 138-144ISSN:0351-0026COBISSID:1108965URN:URN:NBN:SI:doc-433NVDVEslInštitut za varovanje zdravja Republike SlovenijeZdravstveno varstvocepivacepljenjeneželeni učinkipnevmokokiPrimerjava neželenih učinkov po cepljenje proti pnevmokoku in gripi ali samo po cepljenju s pnevmokoknim cepivom| Adverse reactions following pneumococcal and influenza vaccination compared to those after administration of pneumococcal vaccine alone|Background: Influenza virus and Streptococcus pneumoniae are important respiratory pathogens. Since immunization with influenza virus and pneumococcal vaccines is recommended in similar population groups, both vaccines can be administered simultaneously. Adverse effects of simultaneous pneumococcal and influenza vaccination were compared to those occurring with pneumoccoccal immunization alone. Methods: Pneumococcal and influenza vaccination or pneumococcal vaccination alone were performed in 1,285 subjects. Demographic data and data on chronic diseases and allergies were collected before the immunization. General and local adverse reactions were recorded for five days following the vaccination. Results: Completed questionnaires were returned by 861 subjects. No statistically significant differences were found between responders and non-responders, except for a lower number of diabetics in the group of responders, and a lower number of allergic subjects among non-responders. There was no statistically significantdifference in the rate of adverse reactions between the subjects vaccinated with one vaccine and those given two vaccines (with one exception).In general, more untoward reactions were recorded in subjects 65 years of age and in women (except for fever and local oedema). No serious adverse reactions were documented. Conclusions: Simultaneous administration of influenza and pneumococcal vaccine does not increase the rate of adverse events compared to vaccination with pneumococcal vaccine aloneIzhodišča: Virus influence in Streptococcus pneumoniae sta pomembna povzročitelja okužb dihal, proti katerima obstaja cepivo. Cepljenje proti gripi in pnevmokoku je priporočljivo za podobne skupine prebivalstva, zato lahko cepimo hkrati. V študiji smo primerjali pojav neželenih učinkov po hkratnem cepljenju in cepljenju s pnevmokoknim cepivom samim. Metode: V preiskavo smo vključili 1285 oseb, ki so prejele cepivo proti pnevmokoku in gripi, ali samo cepivo proti pnevmokoku. Pred cepljenjem smo zbrali demografske podatke in podatke o kroničnih boleznih ter alergijah. Neželene učinke (splošne in lokalne) po cepljenju so preiskovanci spremljali pet dni injih zapisovali v vprašalnik. Rezultati: Vprašalnik je vrnilo 861 preiskovancev. Statistično značilnih razlik med tistimi, ki so vrnili, in tistimi, ki ga niso vrnili, ni bilo, razen manjšega števila sladkornih bolnikov pri t. i. responderjih in manjšega števila alergikov pri t. i. non-responderjih. Neželeni učinki pri 541 osebah, ki so prejele obe cepivi, in320 osebami, ki so prejele le pnevmokokno cepivo, niso bili statistično značilno različni z eno samo izjemo. Statistično značilno več težav po cepljenju s pnevmokoknim cepivom (samim ali skupaj z gripo) so imele ženske (razen povišane telesne temperature in otekline na mestu cepljenja) in mlajši od 65 let. Pri nobenem nismo zaznali resnih neželenih učinkov. Zaključek: Cepljenje z obema cepivoma hkrati ne poveča števila neželenih učinkov v primerjavi z dajanjem pnevmokoknega cepiva samegaTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaInštitut za varovanje zdravja RS