421 KB33 KB394 KB34 KB192920262022Skamen, UrškaSkamen, UrškaSodja, EvaŽolnir-Dovč, Marijaštevilka:7/8letnik:91str. 265-272DOI:10.6016/ZdravVestn.3251COBISSID:113677827ISSN:1318-0347URN:URN:NBN:SI:doc-2N42DI9PslSlovensko zdravniško društvoZdravniški vestnikdiagnostikaLatent tuberculosisLatentna tuberkulozaMycobacterium tuberculosisrezultatitest QuantiFERON TBtetiranjeTuberculosisTuberkulozaTesta QuantiFERON TB in TB Plus v Sloveniji v obdobju 2008-2019| QuantiFERON TB and TB Plus tests in Slovenia between 2008 and 2019|Background: The QuantiFERON TB (QFT TB) test is primarily intended to detect latent (LTBI) tuberculosis (TB) infections. This work is based on a retrospective analysis of QFT TB test results in Slovenia between 2008 and 2019. It also draws attention to the influence of pre-analytical factors on a test result, on reasons that lead to indeterminate results, and on the sensitivity of the test in patients with active tuberculosis (TB). Methods: Between 2008 and 2019, we performed the QFT TB test in Laboratory for Mycobacteria of the University Clinic Golnik on 29,352 blood samples of patients from various health care institutions in Slovenia. A retrospective analysis was performed on QFT TB test results. Results: The proportion of positive QFT TB test results is gradually decreasing. In 2008, the proportion was 20.8% and in 2019, it declined to 10.7%, meaning that it has decreased by 48.6% in the last 12 years. The biggest problem are indeterminate results (on average 4.3% per year), as they are unpredictive to a physician. The sensitivity of the QFT TB test in patients with active TB is 82.9%, which is comparable to the data from abroad. Conclusion: The QFT TB test is highly sensitive to pre-analytical factors and the clinical condition of subjects therefore it is crucial that we follow instructions regarding blood taking and dispatching. The proportion of positive QFT TB test results has been rapidly declining over the years, which is a consequence of efforts to limit the spread of active TB in our countryIzhodišča: Test QuantiFERON TB (QFT TB) je prvenstveno namenjen za odkrivanje latentne (LTBI) okužbe z bacili tuberkuloze (TB). Članek obsega retrospektivno analizo rezultatov testa QFT TB v Sloveniji med letoma 2008 in 2019, opozarja na vplive predanalitskih dejavnikov na rezultate testa ter govori o razlogih za nastanek nejasnih rezultatov in o občutljivosti testa pri bolnikih z aktivno obliko TB. Metode: V obdobju 2008–2019 smo v Laboratoriju za mikobakterije Klinike Golnik s testom QFT TB testirali 29.352 vzorcev krvi bolnikov iz različnih zdravstvenih ustanov v Sloveniji. Na rezultatih testa QFT TB smo izvedli retrospektivno analizo. Rezultati: Delež pozitivnih rezultatov testa QFT TB se z leti postopno znižuje. V letu 2008 je znašal 20,8 %, v letu 2019 pa 10,7 %, kar pomeni, da je v zadnjih dvanajstih letih upadel za 48,6 %. Največjo težavo predstavljajo nejasni rezultati (letno povprečno 4,3 %), saj so za zdravnika nepovedni. Občutljivost testa QFT TB pri bolnikih z aktivno obliko TB je 82,9 %, kar je primerljivo s podatki iz tujine. Zaključek: Pomembno je, da pri odvzemu in pošiljanju krvi dosledno sledimo navodilom, saj je test QFT TB zelo občutljiv na predanalitske dejavnike in klinično stanje preiskovancev. Delež pozitivnih rezultatov testa QFT TB z leti pospešeno upada, kar je povezano z napori za omejitev širjenja TB in upadom primerov aktivne TB v naši državiTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaSlovensko zdravniško društvo