{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-2H9LEWO2/5d207fdc-a262-46a8-ab16-3c49ffc67fb9/PDF","dcterms:extent":"102 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-2H9LEWO2/b8ae3cbe-9772-4e0f-9dab-7dcd7d62ec80/TEXT","dcterms:extent":"32 KB"}],"edm:TimeSpan":{"@rdf:about":"1929-2026","edm:begin":{"@xml:lang":"en","#text":"1929"},"edm:end":{"@xml:lang":"en","#text":"2026"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-2H9LEWO2","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/urn:nbn:si:spr-a30mfzkp"},{"@xml:lang":"sl","#text":"Zdravniški vestnik"}],"dcterms:issued":"2014","dc:creator":["Cerar, Tjaša","Gregorič, Nadan","Kotnik, Vladimir","Pongrac Barlovič, Draženka","Zorin, Anže"],"dc:format":[{"@xml:lang":"sl","#text":"številka:10"},{"@xml:lang":"sl","#text":"letnik:83"},{"@xml:lang":"sl","#text":"str. 661-669"}],"dc:identifier":["ISSN:1318-0347","COBISSID:31699417","URN:URN:NBN:SI:doc-2H9LEWO2"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"dc:subject":[{"@xml:lang":"en","#text":"complement"},{"@xml:lang":"en","#text":"diabetes"},{"@xml:lang":"sl","#text":"komplement"},{"@xml:lang":"sl","#text":"lektin"},{"@xml:lang":"en","#text":"mannan binding lectin"},{"@xml:lang":"sl","#text":"nefropatija"},{"@xml:lang":"en","#text":"nephropathy"},{"@xml:lang":"sl","#text":"sladkorna bolezen"}],"dcterms:temporal":{"@rdf:resource":"1929-2026"},"dc:title":{"@xml:lang":"sl","#text":"Activation of complement system by mannan pathway and Mbl2 genotypes in patients with type 2 diabetes and nephropathy| Aktivacija komplementnega sistema po mananski poti in genotipi gena Mbl2 pri bolnikih s sladkorno boleznijo tipa 2 in ledvično okvaro|"},"dc:description":{"@xml:lang":"sl","#text":"To add new evidence that complement activation by the mannan (lectin) pathway is involved in the pathogenesis of nephropathy in patients with type 2 diabetes, we collected blood and urine samples from 20 patients with type 2 diabetes and nephropathy and 20 apparently healthy individuals from the general population. We performed tests for complement activation analysis (CH50, APH50, C3, C4, C3d/dg, C4d, SC5b-9, MBL and genotyping of Mbl2 gene) in blood and (C3d/dg, C4d, MBL, and SC5b-9) in urine. We found significant signs of complement activation in patients with type 2 diabetes and nephropathy in blood and in urine. We also observed significant genetic differences between healthy individuals and patients with type 2 diabetes and nephropathy concerning the Mbl2 gene. Healthy individuals were apparently more heterogeneous (45 % A0 type) in presentation of the structural Mbl2 genotype, giving intermediate and low levels of MBL protein, compared to patients with type 2 diabetes and nephropathy, who had a very homogenous Mbl2 genome (75 % AA type) giving a high level of MBL production. From our data we can conclude that patients with type 2 diabetes and nephropathy presents more frequently with Mbl2 gene polymorphism giving high production of the MBL protein, what is very likely connected with acquired renal injury"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-2H9LEWO2","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-2H9LEWO2"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-2H9LEWO2/5d207fdc-a262-46a8-ab16-3c49ffc67fb9/PDF"},"edm:rights":{"@rdf:resource":"http://creativecommons.org/licenses/by-nc/4.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Slovensko zdravniško društvo"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-2H9LEWO2/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-2H9LEWO2"}}}}