{"?xml":{"@version":"1.0"},"edm:RDF":{"@xmlns:dc":"http://purl.org/dc/elements/1.1/","@xmlns:edm":"http://www.europeana.eu/schemas/edm/","@xmlns:wgs84_pos":"http://www.w3.org/2003/01/geo/wgs84_pos","@xmlns:foaf":"http://xmlns.com/foaf/0.1/","@xmlns:rdaGr2":"http://rdvocab.info/ElementsGr2","@xmlns:oai":"http://www.openarchives.org/OAI/2.0/","@xmlns:owl":"http://www.w3.org/2002/07/owl#","@xmlns:rdf":"http://www.w3.org/1999/02/22-rdf-syntax-ns#","@xmlns:ore":"http://www.openarchives.org/ore/terms/","@xmlns:skos":"http://www.w3.org/2004/02/skos/core#","@xmlns:dcterms":"http://purl.org/dc/terms/","edm:WebResource":[{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-2BM5GTGF/4da34fe0-469f-49e9-9a5c-8f01785b66d5/PDF","dcterms:extent":"69 KB"},{"@rdf:about":"http://www.dlib.si/stream/URN:NBN:SI:DOC-2BM5GTGF/cd3dc96f-17fd-4bdd-a203-258aaaa956fe/TEXT","dcterms:extent":"23 KB"}],"edm:TimeSpan":{"@rdf:about":"2004-2025","edm:begin":{"@xml:lang":"en","#text":"2004"},"edm:end":{"@xml:lang":"en","#text":"2025"}},"edm:ProvidedCHO":{"@rdf:about":"URN:NBN:SI:DOC-2BM5GTGF","dcterms:isPartOf":[{"@rdf:resource":"https://www.dlib.si/details/URN:NBN:SI:spr-0I3LSS3I"},{"@xml:lang":"sl","#text":"Slovenian veterinary research"}],"dcterms:issued":"2010","dc:creator":"Živin, Marko","dc:format":[{"@xml:lang":"sl","#text":"številka:4"},{"@xml:lang":"sl","#text":"letnik:47"},{"@xml:lang":"sl","#text":"str. 175-180"}],"dc:identifier":["ISSN:1580-4003","COBISSID:27799513","URN:URN:NBN:SI:doc-2BM5GTGF"],"dc:language":"en","dc:publisher":{"@xml:lang":"sl","#text":"Veterinarska fakulteta"},"dc:subject":[{"@xml:lang":"sl","#text":"antipsihotiki"},{"@xml:lang":"sl","#text":"dopaminski antagonisti"},{"@xml:lang":"sl","#text":"Parkinsonova bolezen"},{"@xml:lang":"sl","#text":"podgane"},{"@xml:lang":"sl","#text":"receptorji"},{"@xml:lang":"sl","#text":"shizofrenija"},{"@xml:lang":"sl","#text":"zasvojenost"},{"@xml:lang":"sl","#text":"zdravila"}],"dcterms:temporal":{"@rdf:resource":"2004-2025"},"dc:title":{"@xml:lang":"sl","#text":"Potential applications of dopamine D1 agonist and D2 antagonist LEK-8829|"},"dc:description":{"@xml:lang":"sl","#text":"Ergoline derivative 9,10-Didehydro-N-methyl-(2-propynyl)-6-methyl-8-aminomethylergoline bimaleinate (LEK-8829), possesses dopamine (DA) D1 agonistic and D2 antagonistic properties in the nigrostriatal and mesocorticolimbic DAergic pathways. These unique dual effects have suggested that LEK-8829 could effectively restore previously imbalanced functional linkage between D1 and D2receptors under schizophrenic conditions in which, LEK-8829 could improve both the negative and positive symptoms of schizophrenia. As dopamine D1 receptor agonist, LEK-8829 may also be beneficial in relieving the motor symptoms of parkinsonism, alone, or when co-administered with antiparkinsonic dopamine D2 agonists, such as ergoline derivative bromocriptine. Moreover, antiparkinsonic potential of LEK-8829 may be particularly useful when the treatment of parkinsonism with D2 agonist drugs is complicated by psychosis. Antiparkinsonic properties of LEK-8829 also suggest a lower propensity of the drug for the induction of extrapyramidal syndrome in the treatment of schizophrenia. Furthermore, by blocking dopamine D2 receptors, LEK-8829 could block the incentive for drug-seeking and drug-craving while by stimulating dopamine D1 receptors it could mediate drug reward and gratification. This implies that LEK-8829 could also attenuate the relapse of psychostimulant drug-addiction, while not being addictive by itself. We conclude that agents with LEK-8829-like dual actions toward dopamine receptors, may represent a newand potent drug class for the treatment parkinsonism, schizophrenia and drug-addiction"},"edm:type":"TEXT","dc:type":[{"@xml:lang":"sl","#text":"znanstveno časopisje"},{"@xml:lang":"en","#text":"journals"},{"@rdf:resource":"http://www.wikidata.org/entity/Q361785"}]},"ore:Aggregation":{"@rdf:about":"http://www.dlib.si/?URN=URN:NBN:SI:DOC-2BM5GTGF","edm:aggregatedCHO":{"@rdf:resource":"URN:NBN:SI:DOC-2BM5GTGF"},"edm:isShownBy":{"@rdf:resource":"http://www.dlib.si/stream/URN:NBN:SI:DOC-2BM5GTGF/4da34fe0-469f-49e9-9a5c-8f01785b66d5/PDF"},"edm:rights":{"@rdf:resource":"http://rightsstatements.org/vocab/InC/1.0/"},"edm:provider":"Slovenian National E-content Aggregator","edm:intermediateProvider":{"@xml:lang":"en","#text":"National and University Library of Slovenia"},"edm:dataProvider":{"@xml:lang":"sl","#text":"Univerza v Ljubljani, Veterinarska fakulteta"},"edm:object":{"@rdf:resource":"http://www.dlib.si/streamdb/URN:NBN:SI:DOC-2BM5GTGF/maxi/edm"},"edm:isShownAt":{"@rdf:resource":"http://www.dlib.si/details/URN:NBN:SI:DOC-2BM5GTGF"}}}}