69 KB3 KB199220251997Fietkau, R...Gramatzki, M...Iro, H...Waldfahrer, F...številka:2letnik:31str. 188-189ISSN:1318-2099COBISSID_HOST:7173081URN:URN:NBN:SI:doc-29GYFUGDenCroatian Medical Association - Croatian Society of RadiologySlovenian Medical Society - Section of RadiologyRadiology and oncology (Ljubljana)Drug therapyHypopharyngeal neoplasmsRadiotherapyTreatment outcomeComparison of sequential and simultaneous chemo-radiotherapy for advanced hypopharyngeal carcinoma - Results of a randomized study|In prospective randomized study, a comparison was drawn between intensified sequential chemo-therapy (arm A) and simulatenous chemo-radiotherapy (arm B) in stage IV hypopharyngeal cancer. G-CSF support was given in both arms; chemotherapy consisted of 2 courses of CDDP (25 mg/m2/d for 5 days) and 5-FU (750 mg/m2/d for 5 days continously). Radiotherapy dosages were 70 Gy on the primary lesion and 60 Gy on the neck. Ninety eight patients were randomized; 60 patients (28 arm A, 32 arm B) finally fulfilled inclusion criteria. Complete remission could be observed in 49% in arm A and in 57% in arm B (p=0.07) and the two-year survival was 27% and 47%, respectivelyTEXTznanstveno časopisjejournalsSlovenian National E-content AggregatorNational and University Library of SloveniaOnkološki inštitut Ljubljana