382 SURGERY, ORTHOPAEDICS, TRAUMATOLOGY Zdrav Vestn | September – October 2022 | Volume 91 | https://doi.org/10.6016/ZdravVestn.3222 Copyright (c) 2022 Slovenian Medical Journal. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Methods of internal sacroiliac fixation – Literature review and case series analysis of iliac screw fixation Metode notranjega fiksiranja križnice na črevnico – Pregled literature in analiza serije primerov fiksiranja z iliakalnim vijakom Janez Mohar Abstract In order to achieve bone fusion between the mobile lumbar spine and the immobile sacrum, surgical techniques have been developed along with the development of instrumentation systems for internal fixation of the thoracolumbar spine that allows the extension and fixation of such systems to the structural elements of the pelvis. The term sacroiliac fixa- tion encompasses all instrumentation systems and surgical techniques for fixation of the lumbosacral spine to the ilium. Nowadays, prevention of pseudarthrosis of the bone fusion at the lumbosacral region, the border between two different structures (mobile lumbar spine and static pelvic ring), is one of the main challenges of surgical treatment of adult lumbar spine deformities. Biomechanically, the lumbosacral junction represents an axis of rotation extending in the lateral plane through the posterior longitudinal ligament at the height of the intervertebral disc of the moving segment L5-S1. The flexion torque arm’s size depends on the number of instrumented movable spine segments. Counter-torque is required for system stability, which, due to the short lever arm, depends mainly on the implant’s attachment strength to the pelvic ring’s bony elements. Sacroiliac fixation systems prevent the formation of pseudoarthrosis of the bone fusion of the lum- bosacral junction. Its occurrence, with the exclusion of biological causes (i.e., infection), depends solely on the strength of the instrumentation system (the brittleness of the material) and the quality of attachment of the instrumentation to the pelvic ring (loss of fixation at the bone-implant interface). Indications for sacroiliac fixation are lumbosacral fusion above the third lumbar vertebra, osteotomies of the lumbar verte- bra, fractures of the sacrum with spinopelvic dissociation, partial or complete sacrectomy, lumbosacral fusion in the face of osteoporotic bone, spondylolisthesis grade III or more of Meyerding classification, correction of kyphotic or scoliotic deformity of the lumbar spine and pelvic obliquity in the frontal plane in neuromuscular deformities of the lumbar spine. This review article aims to describe the spinopelvic junction’s biomechanics, present the developmental history of im- plants and surgical techniques, and describe the modern sacroiliac fixation methods. Valdoltra Orthopaedic Hospital, Ankaran, Slovenia Correspondence / Korespondenca: Janez Mohar, e: janez.mohar@ob-valdoltra.si Key words: spine deformity; pseudoarthrosis; lumbosacral junction; iliac screw; S2-alar-iliac screw Ključne besede: deformacija hrbtenice; psevdoartroza; ledveno-križnični prehod; iliakalni vijak; S2-alarni iliakalni Received / Prispelo: 26. 1. 2021 | Accepted / Sprejeto: 16. 4. 2021 Cite as / Citirajte kot: Mohar J. Methods of internal sacroiliac fixation – Literature review and case series analysis of iliac screw fixation. Zdrav Vestn. 2022;91(9–10):382–92. DOI: https://doi.org/10.6016/ZdravVestn.3222 eng slo element en article-lang 10.6016/ZdravVestn.3222 doi 26.1.2021 date-received 16.4.2021 date-accepted Surgery, orthopaedics, traumatology Kirurgija, ortopedija, travmatologija discipline Review article Pregledni znanstveni članek article-type Methods of internal sacroiliac fixation – Liter- ature review and case series analysis of iliac screw fixation Metode notranjega fiksiranja križnice na črevni- co – Pregled literature in analiza serije primerov fiksiranja z iliakalnim vijakom article-title Methods of internal sacroiliac fixation Metode notranjega fiksiranja križnice na črevnico alt-title spine deformity, pseudoarthrosis, lumbosacral junction, iliac screw, S2-alar-iliac screw deformacija hrbtenice, psevdoartroza, ledve- no-križnični prehod, iliakalni vijak, S2-alarni iliakalni vijak kwd-group The authors declare that there are no conflicts of interest present. Avtorji so izjavili, da ne obstajajo nobeni konkurenčni interesi. conflict year volume first month last month first page last page 2022 91 9 10 382 392 name surname aff email Janez Mohar 1 janez.mohar@ob-valdoltra.si name surname aff eng slo aff-id Valdoltra Orthopaedic Hospital, Ankaran, Slovenia Ortopedska bolnišnica Valdoltra, Ankaran, Slovenija 1 Slovenian Medical Journallovenian Medical Journal 383 REVIEW ARTICLE Methods of internal sacroiliac fixation 1 Introduction Surgical treatment of complex pathology of the thoracolumbar spine is based on the internal fixation of the bone structures involved in the disease pro- cess with the aim of preventing progression, and at the same time, stabilizing the corrected position of the deformed spinal column. Such an “internal fix- ator” is actually a multi-level instrumentation con- struct consisting of pedicle screws, fixated bilaterally to the vertebrae, and rods connecting the heads of the pedicle screws to one another. The instrumentation construct thereby turns the mobile segments of the thoracolumbar spine into an immobile structure of interconnected vertebrae, which is a prerequisite for early mobilization of the patient after surgery. By sta- bilizing the vertebrae, the instrumentation construct allows the bone graft placed on the decorticated bone structures to connect over time into a static bone fusion mass, which permanently fuses the mobile segments included in the construct. Biomechanical- ly, the lumbosacral region is a junction between the mobile lumbar spine and the static pelvic ring. The axis of rotation between these two structures in the lateral plane passes through the posterior longitudi- nal ligament at the height of the intervertebral disc of the L5-S1 moving segment. This anatomical region is therefore the area where both static and dynamic Izvleček Da bi dosegli zatrditev med gibljivo ledveno hrbtenico in negibljivo križnico, so se ob razvoju instrumentacijskih siste- mov za notranje fiksiranje prsno-ledvene hrbtenice razvijale kirurške tehnike, ki omogočajo podaljšati take sisteme na kostne elemente medenice. Izraz sakroiliakalno (SI) fiksiranje zajema vse instrumentacijske sisteme in kirurške tehnike za notranjo učvrstitev ledveno-križničnega predela hrbtenice na črevnico. Preprečevanje psevdoartroze kostne fuzije ledve- no-križničnega prehoda, ki nastane na meji med dvema različnima strukturama (gibljivo ledveno hrbtenico in statičnim medeničnim obročem), je dandanes eden glavnih izzivov kirurškega zdravljenja deformacij ledvene hrbtenice pri odraslih. Ledveno-križnični prehod je biomehansko os vrtenja, ki v stranski ravnini poteka skozi posteriorni longitudinalni ligament v višini medvretenčne ploščice gibljivega segmenta L5-S1. Velikost ročice fleksijskega navora je odvisna od števila instru- mentiranih ravni gibljive prsno-ledvene hrbtenice, za stabilnost sistema pa je potreben nasprotni navor, ki je zaradi kratke ročice odvisen predvsem od pričvrstitvene moči vsadka na kostne elemente medeničnega obroča. Sistemi SI-fiksiranja preprečujejo nastanek psevdoartroze kostne fuzije ledveno-križničnega prehoda, njen pojav pa je ob odsotnosti bioloških vzrokov (npr. okužba) odvisen izključno od trdnosti instrumentacijskega sistema (lomljivost materiala) in kakovosti fiksira- nja instrumentarija na medenični obroč (omajanje na stiku med vsadkom in kostjo). Indikacije za SI-fiksiranje so ledveno-križnična kostna fuzija (zatrditev) več kot treh ledvenih vretenc, razširjene korektivne osteotomije ledvenih vretenc, zlomi križnice s spinopelvično (SP) disociacijo, delna ali popolna sakrektomija, ledveno- -križnična kostna fuzija pri osteoporotični kosti, spondilolisteza, ki je večja od II. stopnje po Meyerdingovi klasifikaciji, korekcija kifotične ali skoliotične deformacije ledvene hrbtenice in nagib medenice v čelni ravnini pri živčnomišičnih de- formacijah ledvene hrbtenice. Pregledni članek opisuje biomehaniko SP prehoda, predstavi zgodovino razvoja vsadkov ter kirurških tehnik in prikaže sodobne metode SI-fiksiranja. load forces are concentrated. When the sacrum and multiple lumbar vertebrae are included in the instru- mentation construct, biomechanical conditions are iatrogenically created that require balancing torques proximal and distal to the axis of rotation in the lumbosacral junction. The magnitude of the flexion torque proximal to the axis of rotation depends on the number of thoracolumbar vertebrae included in the instrumentation construct. The torque distal to the axis of rotation depends on the length of the distal lever arm and on the implant’s attachment strength to the bony elements of the pelvic ring. The prerequi- site for flexion-extension stability is that the implants, which are fixed to the elements of the pelvic ring, run anterior to the axis of rotation. The term SP fixation broadly covers all instrumentation systems and sur- gical techniques for fixation of the lumbar spine to the sacrum, the latter being the biomechanical part of the pelvic ring. Sacroiliac (SI) fixation encompasses all instrumentation systems and surgical techniques for fixation of the lumbosacral spine to the ilium. Pre- venting the formation of pseudarthrosis of bone fu- sion mass of the lumbosacral junction and thus the failure of the instrumentation construct is one of the main challenges of surgical treatment of lumbar spine deformities today (1,2). 384 SURGERY, ORTHOPAEDICS, TRAUMATOLOGY Zdrav Vestn | September – October 2022 | Volume 91 | https://doi.org/10.6016/ZdravVestn.3222 Figure 1: Posterior (A), superior (B), and lateral (C and D) views of the anatomical diagram of the pelvic ring with O’Brien zones marked (zone I = blue, zone II = yellow, zone III = grey) and with the iliac (arrow) and S2AI screws (arrow head) inserted. Indications for SIJ fixation are lumbosacral fusion above the third lumbar vertebrae, extensive corrective osteotomies of the lower thoracic and lumbar verte- brae, fractures of the sacrum with spinopelvic dissoci- ation, partial or complete sacrectomy, lumbosacral fu- sion in the face of osteoporotic bone, spondylolisthesis grades III, IV, and V, kyphotic or scoliotic deformity of the lumbar spine, and unstable sitting position due to pelvic obliquity in the frontal plane in neuromuscular deformities of the lumbar spine (3). SP fixation techniques are divided according to the area of fixation in the sacropelvic region, which is de- fined by O’Brien’s anatomic zones (Figure 1). The at- tachment strength of the distal part of the instrumen- tation construct increases depending on the number of zones included in the construct (4-6). O’Brien zone I consists of the S1 vertebral body and the cranial sacral alae, and SP fixation techniques in this anatomical area are the S1 pedicle screw, L5-S1 transfacet screw, and the Dunn-McCarthy technique. In the latter, the S-shaped rods are posteriorly fixated to the sacral ala. It is suit- able for non-ambulatory children with neuromuscu- lar scoliosis, in whom the pelvis is too small and the iliac cortices are too thin for classic iliac fixation (7). O’Brien zone II consists of the S2 vertebral body, cau- dal sacrum, and coccyx. SP fixation techniques in this anatomical area are the S2 pedicle screw, sacro-alar iliac screw, sacral neural foramina hooks in the form of a jaw construct, and the Jackson technique with intrasacral rods (8). O’Brien zone III constitutes the ilia and the SP fixation techniques in this anatomical area are the Galveston technique, the iliac screw, and the Kostuik transilial bar technique. In order to achieve the greatest possible fixation strength on the pelvic ring, these tech- niques are combined or implants are used that allow fixation through two O’Brien zones at the same time. These are the Chopin block, the Tacoma plate, the Col- orado 2 iliosacral plate, the Warner and Fackler tech- nique, the iliosacral screw, and the S2-alar-iliac screw (S2AI) (9). Biomechanical stress on the fixation construct is significantly reduced with additional stabilization by inserting an intervertebral cage between the L4, L5, and S1 vertebral bodies (L4-L5 and L5-S1 mobile segments of the lumbosacral junction). This reduces micromove- ments anterior to the axis of rotation in the lumbosa- cral junction, the axis of rotation moves proximally, and the intervertebral cage thus provides support to the construct and “protects” it against failure (break- age or loosening of the implants) (10). Biomechanical research has proven that SIJ fixation with iliac screws 385 REVIEW ARTICLE Methods of internal sacroiliac fixation Figure 2: SP fixation with the Luque-Galveston technique in a 13-year-old boy with scoliosis as part of spinal muscular atrophy; anteroposterior (A) and lateral (B) projection (source: Archives of the Department of Orthopaedic Surgery of the University Clinical Centre Ljubljana). reduces the strain on the instrumentation construct more than the intervertebral cage alone (10,11). In- tervertebral cage implantation between the vertebral bodies of the lumbosacral junction is therefore a pre- requisite for all instrumented lumbosacral fusions. In the case of long thoracolumbar-sacral instrumentation constructs, the insertion of the intervertebral cage must always be combined with SIJ fixation. 2 Development of implants for Fixation in O’Brien zone III The first example of an implant in O’Brien zone III was a transiliac rod connecting the iliac alae to which a lumbar instrumentation was attached. This concept was first described as early as 1962 in the form of the Harrington rod, a modification of which was later up- graded by Kostuik with his own implant suitable for more modern and more rigid instrumentation systems (12,13). In the 1970s, when fixing his multisegmental sys- tem of rods and sublaminar wires to the pelvis, Luque curved the distal ends laterally and led them through the posterior alae of ilium. As the Luque L-rod is considered a weak SIJ fixation, it was not able to with- stand physiological flexion and torsion forces (14,15). In 1982, Allen and Ferguson of the University of Tex- as Medical Branch at Galveston described a technique for pelvic fixation with Luque’s segmental instrumenta- tion by inserting extended left and right L-shaped rods into the ilia (16). The Luque-Galveston technique of in- trailiac rod stabilization (Figure 2) became the first bio- mechanically and clinically successful form of fixation of long instrumentation constructs in O’Brien’s zone III. The technique involves the introduction of rod instru- mentation with an entry point at the posterior superior iliac spine, the rod passing between the two cortices of the ilium. The degree of lumbosacral spinal fusion rate using this technique is described to be 88-90% (17,18). Biomechanically, the Luque-Galveston technique does not provide enough resistance to axial traction, which represents the force component during lumbar flexion, so micromovements in the sacroiliac joint can lead to erosive changes in the contact between the rod and the bone (windshield-wiper effect), which results in the loss of the fixation function of the implant. Erosive chang- es do not always lead to clinically expressed pseudoar- throsis, although it is more common in the presence of the “windshield-wiper effect” (18). The described rate of pseudoarthrosis of the lumbosacral junction when using the Luque-Galveston technique in adult spinal deformities varies between 36% and 41% (19,20). An additional weakness of the technique is the demanding, anatomy-adapted bending of the rods that are inserted into the ilium. The Luque-Galveston technique is still a relative indication in non-ambulatory patients with neuromuscular scoliosis, due to the low profile of the implant and the price of the commercially proximally pre-bent U-shaped rod (unit rod). The Luque-Galves- ton intrailiac rod concept later led to the development of SIJ fixation with iliac screws (21). The technique of fixing the lumbar instrumentation to the iliosacral screw was first described in 1973, but later developed in its improved form in the 1980s into the possibility of SIJ fixation with the first generation of hybrid segmental instrumentation with the Cotrel-Du- bousset system (22,23). In this technique, a screw is in- serted from the outer side of the ilium towards the body of the S1 vertebra. The screw provides strong tricortical bone graft (inner and outer cortices of the ilium and posterior cortex of the sacrum). The iliosacral screw as a stand-alone implant in SIJ fixation is connected to the rods of the lumbar instrumentation construct via a connecting element. In this technique, the S1 pedi- cle screws are not used due to possible contact with the 386 SURGERY, ORTHOPAEDICS, TRAUMATOLOGY Zdrav Vestn | September – October 2022 | Volume 91 | https://doi.org/10.6016/ZdravVestn.3222 iliosacral screws within the S1 vertebral body. The tech- nique itself, however, allows considerable modularity in relation to anatomical conditions. Due to the exten- sive dissection along the iliac edge and the possibility of damaging the posterior iliosacral ligament, which triggers sacroiliac joint instability and a high incidence of neurological injuries due to incorrect position of the screw, the use of this technique is currently limited mainly to revision cases (15,23). 3 Modern techniques of SIJ fixation 3.1 Iliac screw Certain shortcomings of the Luque-Galveston tech- nique were overcome by the technique of connecting iliac screws to the rod of the instrumentation construct with modular connectors (24). On the cadaver model, a three times stronger fixation of the iliac screws into the ilium is made possible compared to the Galveston intrailiac rod by the presence of threads and the great- er thickness of the implant (25). The entry point of the iliac screw is at the level of the posterior superior iliac spine or just below it, and the direction (trajectory) of insertion is either towards the superior portion of the acetabula or towards the anterior inferior iliac spine. The latter direction allows the insertion of longer im- plants, is safer regarding the possibility of piercing the acetabular floor and the fixation can be made stronger, since the screw is inserted through a greater narrowing between the cortices of the ilium in its course above the sciatic notch (26). Due to the longer iliac screw, there is a greater possibility for it to go outside the safety tra- jectory and thus for more complications, however, the longer screw enables a stronger fixation to the ilium. Longer iliac screws have been proven to have a greater pull-out force, and under physiologic torsion, and com- pressive loading conditions there should be no statisti- cally significant differences in the mechanical stability of SIJ fixation between shorter and longer iliac screws, but on the condition that the shorter screw also runs anterolaterally of the sciatic notch (27). The gold stan- dard for iliac screw insertion is therefore the thickest and longest possible implant, which runs in the direc- tion of the anterior inferior iliac spine, namely antero- laterally of the sciatic notch. The SIJ fixation construct with iliac screws fails in two ways: either by loosening which causes pseudar- throsis, or by the implant breaking. Loosening of the iliac screw occurs during cyclic micromovements at the bone-implant interface. The phenomenon is common, but in most cases, it is clinically silent, except when the loosening leads to pseudarthrosis (2,28,29). Revision of loose iliac screws is necessary if pseudarthrosis devel- ops, namely by inserting longer and thicker implants, reinforcing the contact between the implant and the bone with bone cement, or by stabilization using dual iliac screws (30-33). The latter technique, i.e. DIS (Du- al Iliac Screw), is primarily suitable for resections and osteotomies of the sacrum and certain forms of sacrum fractures with dislocation of fragments (34). Screw fracture is a rarer form of fixation failure with a reported rate of 5.3%, which more often affects the younger population with good bone quality and insuf- ficient screw diameter (28). The indication and options for revision surgery are otherwise the same as in the case of loosening. The SIJ instrumentation construct in the form of combined S1 pedicle screw and iliac screw has certain disadvantages: • Insertion of the iliac screw requires an extensive lat- eral soft tissue dissection along the iliac crest, thereby creating a surgical “dead space” (a prerequisite for lo- cal infection). • The iliac screw is connected to the rod of the con- struct via a connector, which further reduces the stiffness of the construct and thus represents an ad- ditional locus minoris resistentiae for its failure, while there are no biomechanical differences if the connec- tor is fixed to the rod above or below the S1 pedicle screw (35). The described rate of pseudarthrosis in the lumbosacral junction when using instrumenta- tion with iliac screws in adult spinal deformities var- ies between 6.4% and 14% (19,36). • The head of the iliac screw and the connector repre- sent a significant implant prominence, which is a rel- atively common cause of local pain and revisions (in- cidence between 6% and 22%) (2,19,37). The results of recently published research show a significantly lower rate of this type of complication if the entry point of the iliac screw is below the posterior superi- or iliac spine, or if the screw head is “sunk” deep into the iliac bone (38-40). Under favourable anatomical conditions, the “anatomical” or “subcrestal” entry point of the iliac screw, it is possible to fix the rod on the screw head without using connectors (41). 3.2 S2AI screw The instrumentation construct with the S2AI screw is the latest SIJ fixation technique, which enables sta- bility without the necessary use of connectors, with a 387 REVIEW ARTICLE Methods of internal sacroiliac fixation less prominent screw head, and with less extensive lat- eral soft tissue dissection (42-44). In this technique, a polyaxial screw is inserted through a starting point on the sacrum that is 2–4 mm lateral and 4–8 mm distal to the S1 dorsal foramen (lateral to the midline connect- ing the S1 and S2 foramen), and the trajectory passes through the sacrum, sacroiliac joint and into the ilium in the direction towards the anterior inferior iliac spine (1,21,44). S2AI screw enables a tricortical fixation (pos- terior cortex of the sacrum and both cortices of the sac- roiliac joint) and is suitable for both children and adults (45-48). Insertion of the S2AI screw through the carti- laginous tissue of the sacroiliac joint may increase local postoperative pain and accelerate degenerative changes in the joint (49,50). Additional potential complications are screw misalignment and, rarely, screw head prom- inence in lean subjects with pain over the sacral area. Incorrect position of the S2AI screw with posterior illi- ac wall perforation leads to its reduced fixation streng- ht and thus to reduced stability of the construct, while anterior or inferior prominence of the ilium endangers vital structures in the pelvis and sciatic notch (superior gluteal artery and sciatic nerve) (3,44). 3.3 Comparison between the iliac screw and the S2AI screw Research on biomechanical studies between the iliac screw and the S2AI screw showed statistical comparabil- ity in the strength of the two constructs under different types of strain on cadaver models (51-53). Meta-analy- ses of clinical comparisons between the iliac screw and the S2AI screw published so far have demonstrated a statistically significant reduction in the risk of revision Patient number Gender Age (years) Indication for surgery Levels of instrumentation placement Follow-up time after surgery (months) 1 female 72 iatrogenic deformation T11-ilium 66 2 male 62 iatrogenic deformation T11-ilium 59 3 female 43 adult idiopathic scoliosis T8-ilium 49 4 male 54 iatrogenic deformation T12-ilium 45 5 female 60 sagittal imbalance L2-ilium 44 6 female 48 iatrogenic deformation L3-ilium 44 7 male 64 sagittal imbalance T11-ilium 44 8 female 58 adult idiopathic scoliosis T10-ilium 42 9 female 64 adult idiopathic scoliosis T3-ilium 39 10 female 57 adult idiopathic scoliosis T10-ilium 38 11 female 52 adult idiopathic scoliosis T11-ilium 38 12 male 61 degenerative scoliosis T11-ilium 34 13 female 49 sagittal imbalance L2-ilium 26 14 female 39 congenital deformity L3-ilium 25 15 female 46 syndromic scoliosis T6-ilium 24 16 female 58 adult idiopathic scoliosis T2-ilium 21 17 female 69 degenerative scoliosis T11-ilium 16 18 male 63 degenerative scoliosis T12-ilium 16 19 male 72 iatrogenic deformation T11-ilium 11 20 female 50 adult idiopathic scoliosis T9-ilium 7 Table 1: Patient cohort characteristics. 388 SURGERY, ORTHOPAEDICS, TRAUMATOLOGY Zdrav Vestn | September – October 2022 | Volume 91 | https://doi.org/10.6016/ZdravVestn.3222 Sample characteristics Number Number of patients 20 Gender 6 men / 14 women Age (years) 57 ± 9 (39–72) Number of levels of instrumentation placement 9 (5–18) Follow-up time (months) 34 ± 16 (7–66) Table 2: Descriptive cohort statistics. surgery, wound infection, or implant prominence with local pain after surgery when using the S2AI screw in both adults and children, while the use of an iliac screw increased the risk of the fixation construct loosening or breaking threefold (54-56). Despite the more chal- lenging technique of inserting the S2AI screw through the sacrum and pelvis, and despite concerns about the long-term effect on sacroiliac joint degeneration, for which there is no clinical evidence yet, there is now suf- ficient evidence that SIJ fixation with the S2AI screw is superior to SIJ fixation with an iliac screw (57-65). Figure 3: Revision Case No. 1: Anteroposterior radiographs of the patient’s spine before (A) and after surgery (B). C – the condition after the breakage of the left and right fixation rods (arrowheads) and the breakage of the left iliac screw (circled). D – connection of the broken rods with a connecting link (arrowheads), removal of the proximal part of the iliac screw and fixation of the distal part of the left rod into the sacrum with a sacral-alar screw (arrow). 4 Case series analysis of sacroiliac screw fixation Between July 2015 and June 2020, 20 bilateral SIJ fixations with an iliac screw were performed at the Val- doltra Orthopaedic Hospital, representing the author’s initial series of consecutive cases using this technique (Table 1 and 2). All iliac screws were inserted using the free-hand technique and their position was checked with an X-ray image intensifier during the operation. Due to the expected complexity, three procedures (patients 9, 15 and 16) were performed in two stages during the same hospitalization (in the first stage, the placement of the implants, and in the second stage, de- formity correction). In 15 cases it was a primary op- eration with a predominant idiopathic aetiology, and in five cases it was a revision procedure as part of an iatrogenic deformity, either kyphosis or kyphoscolio- sis. In two patients (number 3 and 16), three revision procedures were performed due to the indication in the area of SIJ fixation (fracture of the iliac screw, local infection, and iliac screw prominence). The retrospec- tive analysis of the case series was approved by the Eth- ics Committee of the Valdoltra Orthopaedic Hospital, 389 REVIEW ARTICLE Methods of internal sacroiliac fixation Figure 4: Revision Case No. 2: X-ray image of the patient’s spine, anteroposterior (A) and lateral (B) before the surgery and anteroposterior (C) and lateral (D) after the surgery. No. 1/2021, on January 20, 2021. The author confirms that he received written consent from both patients for the anonymized medical data and image material publication. 4.1 Revision case No. 1 A 43-year-old patient (No. 3, Table 1) with a rigid, right-sided idiopathic scoliotic curvature of the lum- bar spine between the T12 and L4 vertebrae and the apex of the L2 vertebra underwent a one-stage correc- tion, a posterior instrumented bone fusion between the T8 vertebra and the sacrum, and SIJ fixation (Fig- ures 3A in 3B). Four months after the operation, she was involved in a traffic accident when another vehicle hit hers from behind. On the basis of imaging tests, skeletal damage or a change in the position of the im- plants were ruled out, but chronic pain appeared in the lumbosacral region. Three years after the operation, she sensed a crack in the lumbosacral junction and felt a severe localized pain. Imaging tests showed the failure of the instrumentation construct with fixation rod breakage between the L4 and L5 vertebrae and the left iliac screw breakage (Figure 3C). During the revi- sion procedure, the distal part of the instrumentation was repaired and an intervertebral cage was inserted through the foramen to allow additional intracorpo- real bone fusion (Figure 3D). The explanation for the instrumentation construct failure is the cyclic load- ing on the material and its stress fracture, the cause of which is pseudoarthrosis of the posterior bone fusion between the fourth and fifth lumbar vertebrae (discov- ered during surgery). The occurrence of pseudoarthro- sis was most likely caused by insufficient stabilization of the lumbosacral junction during the first operation, since the intervertebral cage was not inserted at the L5-S1 segment. 4.2 Revision case No. 2 In a 58-year-old patient (no. 16, Table 1) with dou- ble adult idiopathic scoliotic curvature, a two-stage correction, an instrumented bone fusion between the T2 vertebra and the sacrum, and SIJ fixation were per- formed due to the progression of the deformity and persistent pain despite conservative measures (Figure 4). After the surgery, the patient lost some weight, but due to the reduction of subcutaneous fat over the posterior superior iliac spine area, the heads of the iliac screws and both connectors protruded, which 390 SURGERY, ORTHOPAEDICS, TRAUMATOLOGY Zdrav Vestn | September – October 2022 | Volume 91 | https://doi.org/10.6016/ZdravVestn.3222 Figure 5: Revision Case No. 3: image of the patient before the removal of the second iliac screw. The scar after the posterior approach to the spine (arrowhead), the scar after excision of the purulent fistula and removal of the right iliac screw (black arrow) and the prominence of the head of the left iliac screw (white arrow) are visible. References 1. Koller H, Zenner J, Hempfing A, Ferraris L, Meier O. Reinforcement of lumbosacral instrumentation using S1-pedicle screws combined withS2- alar screws. Oper Orthop Traumatol. 2013;25(3):294-314. DOI: 10.1007/ s00064-012-0160-0 PMID: 23519295 2. Tsuchiya K, Bridwell KH, Kuklo TR, Lenke LG, Baldus C. Minimum 5-year analysis of L5-S1 fusion using sacropelvic fixation (bilateral S1 andiliac screws) for spinal deformity. Spine. 2006;31(3):303-8. DOI: 10.1097/01. brs.0000197193.81296.f1 PMID: 16449903 3. Jain A, Hassanzadeh H, Strike SA, Menga EN, Sponseller PD, Kebaish KM. Pelvic Fixation in Adult and Pediatric Spine Surgery: Historical Perspective, Indications,and Techniques: AAOS Exhibit Selection. J Bone Joint Surg Am. 2015;97(18):1521-8. DOI: 10.2106/JBJS.O.00576 PMID: 26378268 4. O’Brien MF. Sacropelvic fixation in spinal deformity. In: DeWald RL, ed. Spinal deformities: the comprehensive text. New York: Thieme; 2003. pp. 601-14. 5. McCord DH, Cunningham BW, Shono Y, Myers JJ, McAfee PC. Biomechanical analysis of lumbosacral fixation. Spine. 1992;17(8):S235- 43. DOI: 10.1097/00007632-199208001-00004 PMID: 1523506 6. Lebwohl NH, Cunningham BW, Dmitriev A, Shimamoto N, Gooch L, Devlin V, et al. Biomechanical comparison of lumbosacral fixation techniques in a calf spine model. Spine. 2002;27(21):2312-20. DOI: 10.1097/00007632- 200211010-00003 PMID: 12438978 irritated the patient locally. Five months after the pro- cedure, there was a perforation of the skin envelope and a fistula with pus discharge above the right illiac screw prominence with systemic and laboratory signs of inflammation. The patient underwent emergency surgery with excision of the fistula, explantation of the right iliac screw and the distal part of the rod with a connector, necrectomy, lavage and drainage, and primary wound closure. Staphylococcus Aureus Spp were isolated from specimens, and the inflammation was cured after several weeks of antibiotic treatment. Nine months after the primary procedure, the left iliac screw was also electively removed due to pronounced localized pain with the patient signing that she is aware of possible later complications related to the loss of strength of the lumbosacral instrumentation con- struct (Figure 5). 5 Conclusion Modern SIJ fixation techniques, such as internal fixation with the iliac and S2AI screws, improve the bone fusion rate after transplantation of a free bone graft into the lumbosacral region. 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