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RAKOTVORNO DELOVANJE KEMIKALIJ IZ OKOLJA 
 
 
POVZETEK.  
 
UVOD 
 za nastanek raka: 
 

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MEHANIZMI DELOVANJA RAKOTVORNIH KEMIKALIJ 


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22
Absorpcija 
 
 
Majhni, nizkomolekularni DNK-adukti najpogosteje nastanejo po alkilaciji 
kovalentne vezave funkcionalne alkilne skupine na molekulo DNK. N a 
splošno je alkilacija dušika nukleinske baze manj mutagena od alkilacije 
 skupino spadajo N-nitrozo spojine in nitrozamini, ki nastajajo tudi endogeno, 


23 
 Reactive Oxygen Species CpG islands

24
 
 
RAKOTVORNO DELOVANJE KADMIJA 


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Slika 3. Mehanizem karcinogenega delovanja kadmija prek indukcije poškodb DNK, inhibicije 
 
 
 
 


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